Share

Combination of Bevacizumab and Lomustine with First Recurrence of Glioblastoma Prolongs PFS but not OS

Results of EORTC trial 26101 presented today at The 20th Annual Scientific Meeting and Education Day of the Society for Neuro-Oncology showed that bevacizumab treatment in patients with progressive glioblastoma, despite prolonged progression-free survival, does not confer a survival advantage.

Prof. Dr. Wolfgang Wick of the Uniklinik Heidelberg and coordinator of this study says, “The future challenge is to identify those patients deriving benefit from that treatment.”

With an annual incidence of approximately five cases per 100,000 persons, gliomas are the most frequently occurring brain tumor in adults. Glioblastomas represent roughly 60-70% of all gliomas, and for this type of glioma there is no curative treatment.

“Standard first line treatment consists of surgical resection followed by radiation and concomitant and adjuvant temozolomide therapy. For recurrence, there are treatment options, but we still have no standard treatment,” points out Dr. Wick. “Phase II data from the BELOB trial had indicated that the combination of bevacizumab and lomustine might produce an overall survival benefit compared with either monotherapy for patients with first progression of a glioblastoma.”

EORTC trial 26101 was coordinated by the EORTC Brain Tumor Group and included 437 patients at 44 sites located in eight countries: Austria, Belgium, France, Germany, Italy, Switzerland, The Netherlands, and the United Kingdom.

This phase 3 trial was supported by an educational grant from F. Hoffmann-La Roche Ltd.

John Bean, PhD
EORTC, Medical Science Writer

Back to news list

Related News

  • EORTC: Advancing research and treatment for rare cancers

  • EORTC Fellowship Programme: celebrating more than 20 years of impactful collaboration

  • Appointment of Malte Peters as EORTC Strategic Alliance Officer

  • Unique series of workshops in partnership with the European Medicines Agency (EMA)

  • EORTC launches a prominent clinical trial in older patients with locally advanced (LA) HNSCC (Head and Neck Squamous Cell Carcinoma)

  • Seven IMMUcan abstracts selected for ESMO Immuno-Oncology Congress 2023

  • EORTC Quality of Life measures integrated in CDISC

  • EORTC and Immunocore are collaborating to launch the ATOM clinical trial of tebentafusp in Adjuvant Uveal Melanoma

  • Treatment with decitabine resulted in a similar survival and fewer adverse events compared with conventional chemotherapy in older fit patients with acute myeloid leukaemia

  • New results and forthcoming EORTC trials in rare cancers, lung, head and neck, and breast carcinomas presented at ESMO 2023