CLIMB 1409

A collaboration project with the European Society of Surgical Oncology (ESSO) and the European Organisation for the Research and Treatment of Cancer (EORTC)

Why we need CLIMB….

An opportunity to do a prospective study for liver metastasis surgery

To answer important questions:

  • Is surgery truly beneficial for initially unresectable CRLM patients?
  • How can we improve surgical strategies?
  • What quality indicators can we use to improve patient care?
  • Is surgery truly beneficial for initially unresectable CRLM patients?
  • How can we improve surgical strategies?
  • What quality indicators can we use to improve patient care?

CLIMB Study Design

Prospective observational cohort study with optional translational research.

Participating sites (ESSO and EORTC Network)

  • Denmark
  • France
  • Italy
  • Netherlands
  • Norway
  • Switzerland
  • United Kingdom

CLIMB Organisation

  • Study Coordinator: Porf. Serge Evrard, Head of the Digestive Tumours Unit, Institut Bergonié, ESSO Clinical Research Director
  • Co-coorinator: Prof. Graeme Poston, Hepatobiliary Center, Aintree University Hospital, ESSO President
  • Clinical Research Fellow: Carmela Isabel Caballero, MD (EORTC)
  • Contact us at 1409@eortc.be

CLIMB Patient Population

  • All patients with colorectal adenocarcinoma with unresectable or initially unresectable liver metastasis who are potential candidates for a surgical procedure.
  • Patient must be discussed within a multidisciplinary tumor board before surgery.

CLIMB Primary Objectives

  1. Evaluate the complications from different surgical strategies for initially unresectable liver metastasis from colorectal cancer.
  2. Develop thresholds for quality parameters for different surgical strategies for initially unresectable liver metastases from colorectal cancer.

CLIMB Secondary Objectives

  1. Determine the long-term outcomes of patients with CRLM who undergo different treatment strategies
  2. Determine the short-term impact of participating in a database in  terms of improved complication rates among participating institutions

CLIMB Database Development

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Dedicated to the memory of our mentors

Professor Lorenzo Cappussoti & Prosfessor Gilles Mentha

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