Clinical Trial Details


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Phase I/II study on induction chemotherapy followed by chemoradiation with or without lapatinib, a dual EGFR/ErbB2 kinase inhibitor, in patients with locally advanced resectable larynx and hypopharynx squamous cell.

Study documentation Publications

Trial Status All trial activities ended
Dates Date of activation: 09-May-2007
Date Step1 close: 04-Nov-2008
Data management at EORTC Yes
Design Phase 1-2
Randomized open
Targeted Sample size All Groups: 127
Treatment Radiotherapy, Drug
Fluorouracil, Carboplatin, Cisplatin, Docetaxel, Lapatinib
Study Staff
Type of cancer Head and Neck
Participating groups EORTC Head and Neck Cancer Group
Participating centers Hopitaux Universitaires Bordet-Erasme - Institut Jules Bordet (Brussels, Belgium) - Inst. 101
Universitair Ziekenhuis Antwerpen (Edegem, Belgium) - Inst. 117
Protocol summary
NCT number NCT00498953
EudraCT 2006-002667-33