Clinical Trial Details

EORTC-24051-HNCG

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Phase I/II study on induction chemotherapy followed by chemoradiation with or without lapatinib, a dual EGFR/ErbB2 kinase inhibitor, in patients with locally advanced resectable larynx and hypopharynx squamous cell.

Study documentation

Trial Status All trial activities ended
Dates Date of activation: 09-May-2007
Date Step1 close: 04-Nov-2008
Data management at EORTC Yes
Design Phase 1-2
Randomized open label
Targeted Sample size All Groups: 127
Treatment Radiotherapy, Drug
Fluorouracil, Carboplatin, Cisplatin, Docetaxel, Lapatinib
Study Staff
Type of cancer Head and Neck
Participating groups EORTC Head and Neck Cancer Group
Recruiting centers Institut Jules Bordet (Anderlecht, Belgium)
Universitair Ziekenhuis Antwerpen (Edegem, Belgium)
Protocol summary http://clinicaltrials.gov/study/NCT00498953
NCT number NCT00498953
EudraCT 2006-002667-33
Financial Support Educational Grant