Clinical Trial Details

EORTC-1559-HNCG

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A pilot study of personalized biomarker-based treatment strategy or immunotherapy in patients with recurrent/metastatic squamous cell carcinoma of the head and neck (UPSTREAM)

Study documentation

Trial Status Closed to Patient Entry
Dates Date of activation: 16-Nov-2017
Date Step1 close: 04-Jul-2023
Data management at EORTC Yes
Design Phase 2
Randomized open label
Treatment Drug
Fluorouracil, Bleomycin, Carboplatin, Docetaxel, Gemcitabine, Methotrexate, Mitomycin, Paclitaxel, Afatinib, Niraparib, Palbociclib, Durvalumab, Monalizumab, Rogaratinib, INCAGN01876, Retifanlimab
Study Staff Jean-Pascal Machiels (Study Coordinator) , Cliniques Universitaires Saint-Luc, Brussels
Amelie Baudhuin (Clinical Operations Assistant) , EORTC Headquarters, Brussels
Jessica Berger (Clinical Research Associate/Monitor) , EORTC Headquarters, Brussels
Laura Decubber (Imaging DM) , EORTC Headquarters, Brussels
Catherine Fortpied (Statistician) , EORTC Headquarters, Brussels
Rachel Galot (Study Co-Coordinator) , Cliniques Universitaires Saint-Luc, Brussels
Anne-Sophie Govaerts (Clinical Scientist) , EORTC Headquarters, Brussels
Ana Joaquim (Clinical Research Physician) , EORTC Headquarters, Brussels
Gracia Katanga (Junior Clinical Operations Manager) , EORTC Headquarters, Brussels
Stephanie Kromar (Regulatory Affairs Manager) , EORTC Headquarters, Brussels
Jeremy Leys (Clinical Operations Manager) , EORTC Headquarters, Brussels
Arnaud Poncin (Data Manager) , EORTC Headquarters, Brussels
Miguel Remis (Lead CRA) , EORTC Headquarters, Brussels
Bette Stofs (Pharmacovigilance Manager) , EORTC Headquarters, Brussels
Konstantina Tsechilidou (Data Manager) , EORTC Headquarters, Brussels
Denisse Tubay (Pharmacovigilance Manager) , EORTC Headquarters, Brussels
Egle Venslovaite (Project Manager) , EORTC Headquarters, Brussels
Yuliya Vostrikova (Data Manager) , EORTC Headquarters, Brussels
Xiao Mang Zhou (Junior RAM) , EORTC Headquarters, Brussels
Athenais van der Elst (Fellow) , EORTC Headquarters, Brussels
Type of cancer Head and Neck
Participating groups EORTC Head and Neck Cancer Group
UNICANCER
National Cancer Research Institute - Head & Neck Cancer Grp
Recruiting centers AZ Groeninge Kortrijk - Campus Kennedylaan (Kortrijk, Belgium)
CHU Helora Pole Hospitalier Jolimont - Hopital Jolimont (Haine-Saint-Paul, Belgium)
CHU Saint-Pierre-Site Porte de Hal (Brussels, Belgium)
CHU Site Sainte-Elisabeth-UCL Namur (Namur, Belgium)
CHU de Bordeaux - Groupe Hospitalier Saint-Andre - Hopital Saint-Andre (BORDEAUX CEDEX, France)
Centre Antoine Lacassagne (NICE CEDEX 2, France)
Centre Georges-Francois-Leclerc (DIJON CEDEX, France)
Centre Oscar Lambret (LILLE CEDEX, France)
Centre de Radiotherapie Pierre Curie (Beuvry, France)
Cliniques Universitaires Saint-Luc (Brussels, Belgium)
GasthuisZusters Antwerpen - Sint-Augustinus (Wilrijk, Belgium)
Grand Hopital de Charleroi - Site Notre Dame (Charleroi, Belgium)
Gustave Roussy (VILLEJUIF CEDEX, France)
Hospital Clinico Universitario De Valencia (Valencia, Spain)
Hospital Universitari Vall d’Hebron -Vall d'Hebron Institut Oncologia (Barcelona, Spain)
Hospital Universitario 12 De Octubre (Madrid, Spain)
Hospital Universitario San Carlos (Madrid, Spain)
ICO L’Hospitalet - Hospital Duran i Reynals (Institut Catala D'Oncologia) (L' Hospitalet De Llobregat, Spain)
IRCCS - Fondazione Istituto Nazionale dei Tumori (Milano, Italy)
Institut Curie- Hopital de Paris (PARIS CEDEX 05, France)
Institut Jules Bordet (Anderlecht, Belgium)
Institut de Cancerologie Strasbourg Europe (formar Paul Strauss) (Strasbourg, France)
Institut de Cancerologie de Lorraine (VANDOEUVRE LES NANCY CEDEX, France)
Institut de Cancerologie de l’Ouest (ICO) - Saint Herblain (Saint Herblain CEDEX, France)
NHS Greater Glasgow and Clyde - Beatson West of Scotland Cancer Centre - Gartnavel General Hospital (Glasgow, United Kingdom)
NHS Lothian - Western General Hospital (Edinburgh, United Kingdom)
Oxford University Hospitals NHS Trust - Churchill Hospital (Oxford, United Kingdom)
Sheffield Teaching Hospitals NHS Foundation Trust - Weston Park Hospital (Sheffield, United Kingdom)
U.Z. Leuven - Campus Gasthuisberg (Leuven, Belgium)
Univ. of Florence -Azienda Ospedaliero-Universitaria Careggi (Firenze, Italy)
Universitair Ziekenhuis Antwerpen (Edegem, Belgium)
Universitair Ziekenhuis Gent (Gent, Belgium)
Protocol summary http://clinicaltrials.gov/study/NCT03088059
NCT number NCT03088059
EudraCT 2017-000086-74
Financial Support Cliniques Univ. Louvain
Pfizer BE