EORTC-26053-22054-BTG-ROG

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Phase III trial on concurrent and adjuvant temozolomide chemotherapy in non-1p/19q deleted anaplastic glioma. The CATNON intergroup trial.

Study documentation

Trial Status	Closed to Patient Entry
Dates	Date of activation: 03-Dec-2007 Date Step1 close: 16-Sep-2015 Date Step2 close: 06-Oct-2015
Data management at EORTC	Yes
Design	Phase 3 Randomized open label
Targeted Sample size	EORTC Groups: 550 - All Groups: 748
Treatment	Radiotherapy, Drug Temozolomide
Study Staff	Martin J. van den Bent (Study Coordinator) , Erasmus MC, Rotterdam Carolina Fernandes (Clinical Operations Manager) , EORTC Headquarters, Brussels Vassilis Golfinopoulos (Clinical Research Physician) , EORTC Headquarters, Brussels Thierry Gorlia (Statistician) , EORTC Headquarters, Brussels Marie-Ange Lentz (Data Manager) , EORTC Headquarters, Brussels Sara Meloen (Pharmacovigilance Manager) , EORTC Headquarters, Brussels Miriam Presas (Junior RAM) , EORTC Headquarters, Brussels Nabila Sebti (Data Manager) , EORTC Headquarters, Brussels
Type of cancer	Brain
Participating groups	EORTC Brain Tumor Group EORTC Radiation Oncology Group NCIC Clinical Trial Group Radiation Therapy Oncology Group Cancer Trials Support Unit Cooperative Trials Group for Neuro-Oncology University College of London
Recruiting centers	APHP Sorbonne Univ - Hopital la Pitie-Salpetriere (PARIS, France) AUSL Bologna - Ospedale Bellaria (Bologna, Italy) AZ Sint-Lucas & Volkskliniek (Gent, Belgium) AZ Sint-Lucas & Volkskliniek (Gent, Belgium) Akron City Hospital - Summa Health System (Akron, United States of America) Alfred Hospital (Prahran, Australia) Allan Blair Cancer Centre (Regina, Saskatchewan, Canada) Altru Cancer Center (Grand Forks, United States of America) Amsterdam UMC - Locatie AMC (Amsterdam, Netherlands) Amsterdam UMC - locatie VUMC (Amsterdam, Netherlands) Austin Health - Austin hospital (Heidelberg VIC, Australia) Azienda Ospedaliera Città della Salute e della Scienza di Torino - Ospedale San Giovanni - Dipartimento Neuroscienze (Torino, Italy) Barnes West County Hospital (Saint Louis, United States of America) Brigham and Women's Hospital (Boston, United States of America) CHRU de Nancy - Hopital Central (NANCY CEDEX, France) Cadence Cancer Center in Warrenville (Warrenville, United States of America) Cambridge University Hospital NHS - Addenbrookes Hospital (Cambridge, United Kingdom) Cancer Care Center, Incorporated (Salem, United States of America) Cancer Treatment Center (Wooster, United States of America) Cancercare Manitoba (Winnipeg, Canada) Carolinas Medical Center (Charlotte, United States of America) Cedars-Sinai Medical Center (Los Angeles, United States of America) Centre Antoine Lacassagne (NICE CEDEX 2, France) Centre Eugene Marquis (RENNES CEDEX, France) Centre Georges-Francois-Leclerc (DIJON CEDEX, France) Centre Hospitalier de l'Université de Montreal - Hopital Notre-Dame (Montreal, Canada) Clatterbridge Cancer Center - Wirral (Wirral, United Kingdom) Cleveland Clinic Foundation (Cleveland, United States of America) Cliniques Universitaires Saint-Luc (Brussels, Belgium) Columbia University Medical Center (New York, United States of America) Community Cancer Center Foundation (Normal, United States of America) Dartmouth Hitchcock Medical Center (Lebanon, United States of America) Derriford Hospital (Plymouth, United Kingdom) Derriford Hospital (Plymouth, United Kingdom) Dixie Medical Center Regional Cancer Center (Saint George, United States of America) Emory University (Atlanta, United States of America) Erasmus MC (Rotterdam, Netherlands) Flinders Medical Centre (Bedford Park, Australia) Florida Hospital (Orlando, United States of America) Gloucestershire Hospital NHS Foundation Trust - Cheltenham General Hospital (Cheltenham, United Kingdom) Grand Hopital de Charleroi - Site Notre Dame (Charleroi, Belgium) Gustave Roussy (VILLEJUIF CEDEX, France) Guy s and St Thomas' NHS - Guy's Hospital (London, United Kingdom) Haaglanden MC - locatie Antoniushove ( Leidschendam, Netherlands) Haaglanden MC - locatie Antoniushove ( Leidschendam, Netherlands) Henry Ford Hospital (Detroit, United States of America) Highland Hospital (Rochester, United States of America) Hopital de La Timone (APHM) (MARSEILLE, France) Hopitaux universitaires de Geneve - HUG - site de Cluse-Roseraie (Geneve, Switzerland) Hopitaux universitaires de Geneve - HUG - site de Cluse-Roseraie (Geneve, Switzerland) Hospital Clinic de Barcelona (Barcelona, Spain) Hull and East Yorkshire Hospitals NHS Trust - Castle Hill Hospital (Cottingham, United Kingdom) ICO Badalona - Hospital Germans Trias i Pujol (Institut Catala D'Oncologia) (Badalona - (Barcelona), Spain) IRCCS - Istituto Neurologico Carlo Besta (Milano, Italy) Illinois CancerCare-Peoria (Peoria, United States of America) Imperial College Healthcare NHS Trust - Charing Cross Hospital (London, United Kingdom) Instituut Verbeeten (Tilburg, Netherlands) Intermountain Medical Center (Murray, United States of America) Kirklin Clinic Acton Road (Birmingham, United States of America) LDS Hospital (Salt Lake City, United States of America) Lake University Ireland Cancer Center (Mentor, United States of America) Lancashire Teaching Hospitals NHS Foundation Trust - Royal Preston Hospital (Preston, United Kingdom) Leeds Teaching Hospitals NHS Trust - St. James's University Hospital (Leeds, United Kingdom) Lehigh Valley Hospital (Allentown, United States of America) London Regional Cancer Center (London, Canada) Loyola University Medical Center (Maywood, United States of America) Maastro Clinic - Maastricht Radiation Oncology (Maastricht, Netherlands) Maidstone & Tunbridge Wells NHS Trust - Maidstone Hospital (Maidstone, United Kingdom) Maine Medical Center (Scarborough, United States of America) Massachussets General Hospital Cancer Center (Boston, United States of America) Mayo Clinic (Rochester, United States of America) Mayo Clinic (Rochester, United States of America) Mayo Clinic in Florida (Jacksonville, United States of America) McKay-Dee Hospital Center (Ogden, United States of America) Medical University of South Carolina-CT services at Univ. Med Center (Charleston, United States of America) Medizinische Hochschule Hannover (Hannover, Germany) Methodist Hospital - Main location (Houston, United States of America) NHS Greater Glasgow and Clyde - Beatson West of Scotland Cancer Centre - Gartnavel General Hospital (Glasgow, United Kingdom) NHS Lothian - Western General Hospital (Edinburgh, United Kingdom) Nebraska Medical Center (Omaha, United States of America) Newcastle Hospitals NHS Trust - Freeman Hospital, Northern Centre For Cancer Care (Newcastle upon Tyne, United Kingdom) Northwestern University Hospital (Chicago, United States of America) Nottingham University Hospitals NHS Trust - City Hospital (Nottingham, United Kingdom) OSF Saint Francis Medical Center (Peoria, United States of America) OSF Saint Francis Radiation Oncology (Peoria, United States of America) Ohio State University Medical Center (Columbus, United States of America) Oncology Associates PC (Fort Wayne, United States of America) Oxford University Hospitals NHS Trust - Churchill Hospital (Oxford, United Kingdom) Parkview Hospital (Fort Wayne, United States of America) Pekin Cancer Treatment Center (Pekin, United States of America) Penn State M.S. Hershey Medical Center (Hershey, United States of America) Piedmont Fayette Hospital (Fayetteville, United States of America) Piedmont Hospital (Atlanta, United States of America) Prince Of Wales Hospital (Randwick - Sydney, Australia) Princess Alexandra Hospital - University Of Queensland (Woolloongabba, Brisbane, Australia) Providence Regional Cancer Partnership (Everett, United States of America) Radboud University Medical Center Nijmegen (Nijmegen, Netherlands) Rapid City Regional Hospital (Rapid City, United States of America) Royal Brisbane And Women's Hospital (Herston - Brisbane, Australia) Royal Hobart Hospital (Hobart, Australia) Royal Melbourne Hospital (Parkville, Australia) Royal North Shore Hospital (St Leonards, Australia) Royal Prince Alfred Hospital (Sydney, Australia) S.B. Marmara Universitesi Pendik Egitim ve Arastirma Hastanesi (Istanbul, Turkey) Saint Luke's University Hospital, Bethlehem Campus (Bethlehem, United States of America) Saskatoon Cancer Centre (Saskatoon, Saskatchewan, Canada) Sheffield Teaching Hospitals NHS Foundation Trust - Weston Park Hospital (Sheffield, United Kingdom) Siouxland Regional Cancer Center (Sioux City, United States of America) Sir Charles Gairdner Hospital (Nedlands, Australia) Siteman Cancer Center-South County (St Louis, United States of America) Siteman Cancer center- St. Louis (St Louis, United States of America) Skagit Valley Hospital (Mount Vernon, United States of America) Southwest General Health Center Ireland Cancer Center (Middleburg Heights, United States of America) Spartanburg Regional Medical Center (Spartanburg, United States of America) St Vincent'S Hospital (Fitzroy (melbourne), Australia) Summa Barberton Hospital (Barberton, United States of America) Summa Health Center at Lake Medina (Medina, United States of America) Swedish Cancer Institute (Seattle, United States of America) Tacoma General Hospital - Northwest CCOP (Tacoma, United States of America) The Christie NHS Foundation Trust (Manchester, United Kingdom) The University of Texas MD Anderson Cancer Center (Houston, United States of America) Tom Baker Cancer Centre (Calgary, Canada) Tri-Cities Cancer Center (Kennewick, United States of America) U.Z. Leuven - Campus Gasthuisberg (Leuven, Belgium) UCSF University of California San Francisco Medical Center-Mount Zion (San Francisco, United States of America) UHB-Queen Elizabeth Medical Centre (Birmingham, United Kingdom) UHHS - Westlake Medical Center (Westlake, United States of America) UHHS-Chagrin Highlands Medical Center (Orange Village, United States of America) UPMC - Heritage Valley Health System - The Medical Center (Beaver, United States of America) UniversitaetsKlinikum Heidelberg - Head Hospital (Heidelberg, Germany) UniversitaetsSpital Zurich (Zurich, Switzerland) Universitaetsklinikum Bonn (Bonn, Germany) Universitaetsklinikum Carl Gustav Carus (TUD) (Dresden, Germany) Universitaetsklinikum Koeln (Koeln, Germany) Universitaetsklinikum Leipzig-Klinik fuer Strahlentherapie und Radioonkologie (Leipzig, Germany) Universitaetsklinikum Regensburg (Regensburg, Germany) Universitaetsklinikum Tuebingen- Crona Kliniken (Tuebingen, Germany) Universitair Ziekenhuis Brussel (Brussels, Belgium) University Health Network - Oci / Princess Margaret Hospital (Toronto, Canada) University Hospital Southampton NHS Foundation Trust - Southampton General Hospital (Southampton, United Kingdom) University Hospital Southampton NHS Foundation Trust - Southampton General Hospital (Southampton, United Kingdom) University Hospitals Bristol NHS Foundation Trust - Bristol Haematology And Oncology Centre (Bristol, United Kingdom) University Medical Center Groningen (Groningen, Netherlands) University Of Kansas Cancer Center- (Kansas City, United States of America) University of Alabama at Birmingham (Birmingham, United States of America) University of Florida (Gainesville, United States of America) University of Kentuky (Lexington, United States of America) University of New Mexico, Cancer Care Alliance (Albuquerque, United States of America) University of Oklahoma - Health Science Center (Oklahoma City, United States of America) University of Rochester - James P. Wilmot Cancer Center (Rochester, United States of America) University of Texas Medical Branch (Galveston, United States of America) University of Texas Southwestern Medical Center (Dallas, United States of America) University of Washington Medical Center (Seattle, United States of America) University of Wisconsin Hospital and Clinics - Comprehensive Cancer Center (Madison, United States of America) Upstate University Hospital (New York, United States of America) Utah Valley Regional Medical Center (Provo, United States of America) Via Christi Regional Medical Center (Wichita, United States of America) Virginia Commonwealth University/Massey Cancer Center (Richmond, United States of America) Waukesha Memorial Hospital (Waukesha, United States of America) Wesley Medical Center (Wichita, United States of America) Western Reserve University (Cleveland, United States of America) Westmead Hospital - Crown Princess Mary Cancer Center (Westmead, Australia) ZNA Middelheim (Antwerpen, Belgium)
Protocol summary	http://clinicaltrials.gov/study/NCT00626990
NCT number	NCT00626990
EudraCT	2006-001533-17
Financial Support	Educational Grant