Clinical Trial Details

EORTC-26053-22054-BTG-ROG

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Phase III trial on concurrent and adjuvant temozolomide chemotherapy in non-1p/19q deleted anaplastic glioma. The CATNON intergroup trial.

Study documentation Publications

Trial Status Closed to Patient Entry
Dates Date of activation: 03-Dec-2007
Date Step1 close: 16-Sep-2015
Date Step2 close: 06-Oct-2015
Data management at EORTC Yes
Design Phase 3
Randomized open label
Targeted Sample size EORTC Groups: 550 - All Groups: 748
Treatment Radiotherapy, Drug
Temozolomide
Study Staff Martin J. van den Bent (Study Coordinator) , Erasmus MC , Rotterdam
Kin Jip Cheung (Senior Clinical Operations Manager) , EORTC Headquarters, Brussels
Giuliana Crucitti (Regulatory Affairs Manager) , EORTC Headquarters, Brussels
Vassilis Golfinopoulos (Clinical Research Physician) , EORTC Headquarters, Brussels
Thierry Gorlia (Statistician) , EORTC Headquarters, Brussels
Sara Meloen (Pharmacovigilance Manager) , EORTC Headquarters, Brussels
Fiona Namanya (Clinical Operations Assistant) , EORTC Headquarters, Brussels
Sara Nicolas (Regulatory Affairs Manager) , EORTC Headquarters, Brussels
Christine Olungu (Data Manager) , EORTC Headquarters, Brussels
Nabila Sebti (Data Manager) , EORTC Headquarters, Brussels
Type of cancer Brain
Participating groups EORTC Brain Tumor Group
EORTC Radiation Oncology Group
NCIC Clinical Trial Group
Radiation Therapy Oncology Group
Cancer Trials Support Unit
Cooperative Trials Group for Neuro-Oncology
University College of London
Recruiting centers AUSL Bologna - Ospedale Bellaria (Bologna, Italy)
Adventist La Grange Memorial Hospital (La Grange, United States of America)
Akron City Hospital - Summa Health System (Akron, United States of America)
Alfred Hospital (Prahran, Australia)
Algemeen Ziekenhuis Sint Lucas (Gent, Belgium)
Algemeen Ziekenhuis Sint Lucas (Gent, Belgium)
Allan Blair Cancer Centre (Regina, Saskatchewan, Canada)
Altru Cancer Center (Grand Forks, United States of America)
Amsterdam UMC - Locatie AMC (Amsterdam, Netherlands)
Amsterdam UMC - locatie VUMC (Amsterdam, Netherlands)
Assistance Publique - Hopitaux de Paris - La Pitie Salpetriere (Paris, France)
Austin Health - Austin hospital (Heidelberg VIC, Australia)
Azienda Ospedaliera Città della Salute e della Scienza di Torino - Ospedale San Giovanni - Dipartimento Neuroscienze (Torino, Italy)
Barnes West County Hospital (Saint Louis, United States of America)
Brigham and Women's Hospital (Boston, United States of America)
Cadence Cancer Center in Warrenville (Warrenville, United States of America)
Cambridge University Hospital NHS - Addenbrookes Hospital (Cambridge, United Kingdom)
Cancer Care Center, Incorporated (Salem, United States of America)
Cancer Treatment Center (Wooster, United States of America)
Cancercare Manitoba (Winnipeg, Canada)
Carolinas Medical Center (Charlotte, United States of America)
Cedars-Sinai Medical Center (Los Angeles, United States of America)
Centre Antoine Lacassagne (Nice, France)
Centre Eugene Marquis (Rennes, France)
Centre Georges-Francois-Leclerc (Dijon, France)
Centre Georges-Francois-Leclerc (Dijon, France)
Centre Hospitalier de l'Université de Montreal - Hopital Notre-Dame (Montreal, Canada)
Clatterbridge NHS -Wirral (Wirral, United Kingdom)
Cleveland Clinic Foundation (Cleveland, United States of America)
Cliniques Universitaires Saint-Luc (Brussels, Belgium)
Cliniques Universitaires Saint-Luc (Brussels, Belgium)
Columbia University Medical Center (New York, United States of America)
Community Cancer Center Foundation (Normal, United States of America)
Dartmouth Hitchcock Medical Center (Lebanon, United States of America)
Derriford Hospital (Plymouth, United Kingdom)
Derriford Hospital (Plymouth, United Kingdom)
Dixie Medical Center Regional Cancer Center (Saint George, United States of America)
Emory University (Atlanta, United States of America)
Erasmus MC (Rotterdam, Netherlands)
Flinders Medical Centre (Bedford Park, Australia)
Florida Hospital (Orlando, United States of America)
Gloucestershire Hospital NHS Foundation Trust - Cheltenham General Hospital (Cheltenham, United Kingdom)
Grand Hopital de Charleroi - Site Notre Dame (Charleroi, Belgium)
Gustave Roussy (Villejuif, France)
Guy s and St Thomas' NHS - Guy's Hospital (London, United Kingdom)
Haaglanden MC - locatie Antoniushove ( Leidschendam, Netherlands)
Hamilton Health Sciences, Juravinski Cancer Centre (Hamilton, Canada)
Henry Ford Hospital (Detroit, United States of America)
Highland Hospital (Rochester, United States of America)
Hopital de La Timone (APHM) (Marseille, France)
Hospital Clinic Universitari de Barcelona (Barcelona, Spain)
Hull and East Yorkshire Hospitals NHS Trust - Castle Hill Hospital (Cottingham, United Kingdom)
Hôpitaux universitaires de Genève - HUG - site de Cluse-Roseraie (Geneve, Switzerland)
ICO Badalona - Hospital Germans Trias i Pujol (Institut Catala D'Oncologia) (Badalona - (Barcelona), Spain)
IRCCS - Istituto Neurologico Carlo Besta (Milano, Italy)
Illinois CancerCare-Peoria (Peoria, United States of America)
Imperial College Healthcare NHS Trust - Charing Cross Hospital (London, United Kingdom)
Instituut Verbeeten (Tilburg, Netherlands)
Intermountain Medical Center (Murray, United States of America)
Kaiser Permanente Los Angeles Medical Center (Los Angeles, United States of America)
Kirklin Clinic Acton Road (Birmingham, United States of America)
LDS Hospital (Salt Lake City, United States of America)
Lake University Ireland Cancer Center (Mentor, United States of America)
Lancashire Teaching Hospitals NHS Foundation Trust - Royal Preston Hospital (Preston, United Kingdom)
Leeds Teaching Hospitals NHS Trust - St. James's University Hospital (Leeds, United Kingdom)
Lehigh Valley Hospital (Allentown, United States of America)
London Regional Cancer Center (London, Canada)
Loyola University Medical Center (Maywood, United States of America)
Maastro Clinic - Maastricht Radiation Oncology (Maastricht, Netherlands)
Maidstone & Tunbridge Wells NHS Trust - Maidstone Hospital (Maidstone, United Kingdom)
Maine Medical Center (Scarborough, United States of America)
Massachussets General Hospital Cancer Center (Boston, United States of America)
Mayo Clinic (Rochester, United States of America)
Mayo Clinic (Rochester, United States of America)
Mayo Clinic in Florida (Jacksonville, United States of America)
McKay-Dee Hospital Center (Ogden, United States of America)
Medical University of South Carolina (Charleston, United States of America)
Medizinische Hochschule Hannover (Hannover, Germany)
Memorial Health University Medical Center (Savannah, United States of America)
Methodist Hospital (Houston, United States of America)
MetroHealth Medical Center (Cleveland, United States of America)
NHS Greater Glasgow and Clyde - Beatson West of Scotland Cancer Centre - Gartnavel General Hospital (Glasgow, United Kingdom)
NHS Lothian - Western General Hospital (Edinburgh, United Kingdom)
Nebraska Medical Center (Omaha, United States of America)
Newcastle Hospitals NHS Trust - Freeman Hospital, Northern Centre For Cancer Care (Newcastle upon Tyne, United Kingdom)
Northwestern University (Chicago, United States of America)
Nottingham University Hospitals NHS Trust - City Hospital (Nottingham, United Kingdom)
OSF Saint Francis Medical Center (Peoria, United States of America)
OSF Saint Francis Medical Center - Radiation Oncology Service at the Central Illinois Comprehensive CC (Peoria, United States of America)
Ohio State University Medical Center (Columbus, United States of America)
Oncology Associates PC (Fort Wayne, United States of America)
Ospedale San Raffaele (Milano, Italy)
Oxford University Hospitals NHS Trust - Churchill Hospital (Oxford, United Kingdom)
Parkview Hospital (Fort Wayne, United States of America)
Pekin Cancer Treatment Center (Pekin, United States of America)
Penn State M.S. Hershey Medical Center (Hershey, United States of America)
Piedmont Fayette Hospital (Fayetteville, United States of America)
Piedmont Hospital (Atlanta, United States of America)
Prince Of Wales Hospital (Randwick - Sydney, Australia)
Princess Alexandra Hospital - University Of Queensland (Woolloongabba, Brisbane, Australia)
Providence Regional Cancer Partnership (Everett, United States of America)
Radboud University Medical Center Nijmegen (Nijmegen, Netherlands)
Rapid City Regional Hospital (Rapid City, United States of America)
Reading Hospital and Medical Center (West Reading, United States of America)
Royal Brisbane And Women's Hospital (Herston - Brisbane, Australia)
Royal Hobart Hospital (Hobart, Australia)
Royal North Shore Hospital (St Leonards, Australia)
Royal Prince Alfred Hospital (Sydney, Australia)
Royal Sussex County Hospital (Brighton, United Kingdom)
S.B. Marmara Universitesi Pendik Egitim ve Arastirma Hastanesi (Istanbul, Turkey)
Saint Luke's University Hospital, Bethlehem Campus (Bethlehem, United States of America)
Saint Mary's Hospital (Green Bay, United States of America)
Saint Vincent Hospital (Green Bay, United States of America)
Saint Vincent Oncology Center (Indianapolis, United States of America)
Saskatoon Cancer Centre (Saskatoon, Saskatchewan, Canada)
Sheffield Teaching Hospitals NHS Foundation Trust - Weston Park Hospital (Sheffield, United Kingdom)
Siouxland Regional Cancer Center (Sioux City, United States of America)
Sir Charles Gairdner Hospital (Nedlands, Australia)
Siteman Cancer Center-South County (Saint Louis, United States of America)
Skagit Valley Hospital (Mount Vernon, United States of America)
Southwest General Health Center Ireland Cancer Center (Middleburg Heights, United States of America)
Spartanburg Regional Medical Center (Spartanburg, United States of America)
St John's Mercy Medical Center (St Louis, United States of America)
St Vincent'S Hospital (Fitzroy (melbourne), Australia)
State University of New York Upstate Medical University (New York, United States of America)
Summa Barberton Hospital (Barberton, United States of America)
Summa Health Center at Lake Medina (Medina, United States of America)
Swedish Cancer Institute (Seattle, United States of America)
Tacoma General Hospital - Northwest CCOP (Tacoma, United States of America)
The Christie NHS Foundation Trust (Manchester, United Kingdom)
The University of Texas MD Anderson Cancer Center (Houston, United States of America)
Tom Baker Cancer Centre (Calgary, Canada)
Tri-Cities Cancer Center (Kennewick, United States of America)
U.Z. Leuven - Campus Gasthuisberg (Leuven, Belgium)
UCSF University of California San Francisco Medical Center-Mount Zion (San Francisco, United States of America)
UHB-Queen Elisabeth Medical Centre (Birmingham, United Kingdom)
UHHS - Westlake Medical Center (Westlake, United States of America)
UHHS-Chagrin Highlands Medical Center (Orange Village, United States of America)
UPMC - Heritage Valley Health System - The Medical Center (Beaver, United States of America)
UniversitaetsKlinikum Heidelberg - Head Hospital (Heidelberg, Germany)
UniversitaetsSpital Zurich (Zurich, Switzerland)
Universitaetsklinikum Bonn (Bonn, Germany)
Universitaetsklinikum Carl Gustav Carus (Dresden, Germany)
Universitaetsklinikum Koeln (Koeln, Germany)
Universitaetsklinikum Leipzig-Klinik fuer Strahlentherapie und Radioonkologie (Leipzig, Germany)
Universitaetsklinikum Regensburg (Regensburg, Germany)
Universitaetsklinikum Tuebingen- Crona Kliniken (Tuebingen, Germany)
Universitair Ziekenhuis Brussel (Brussels, Belgium)
University Health Network - Oci / Princess Margaret Hospital (Toronto, Canada)
University Hospital Southampton NHS Foundation Trust - Southampton General Hospital (Southampton, United Kingdom)
University Hospitals Bristol NHS Foundation Trust - Bristol Haematology And Oncology Centre (Bristol, United Kingdom)
University Medical Center Groningen (Groningen, Netherlands)
University Of Kansas (Kansas City, United States of America)
University Of Utah - Huntsman Cancer Institute (Salt Lake City, United States of America)
University of Alabama at Birmingham (Birmingham, United States of America)
University of Alberta - Cross Cancer Institute (Edmonton, Canada)
University of Florida (Gainesville, United States of America)
University of Kentuky (Lexington, United States of America)
University of New Mexico, Cancer Care Alliance (Albuquerque, United States of America)
University of Oklahoma - Health Science Center (Oklahoma City, United States of America)
University of Rochester - James P. Wilmot Cancer Center (Rochester, United States of America)
University of Texas Medical Branch (Galveston, United States of America)
University of Texas Medical Branch - Cancer Center at Victory Lakes (League City, United States of America)
University of Texas Southwestern Medical Center (Dallas, United States of America)
University of Washington Medical Center (Seattle, United States of America)
University of Wisconsin Hospital and Clinics - Comprehensive Cancer Center (Madison, United States of America)
Utah Valley Regional Medical Center (Provo, United States of America)
Via Christi Regional Medical Center (Wichita, United States of America)
Virginia Commonwealth University/Massey Cancer Center (Richmond, United States of America)
Virginia Mason CCOP (Seattle, United States of America)
Washington University School of Medicine - St. Louis (Saint Louis, United States of America)
Waukesha Memorial Hospital (Waukesha, United States of America)
Wesley Medical Center (Wichita, United States of America)
Western Reserve University (Cleveland, United States of America)
Westmead Hospital (Westmead, Australia)
ZNA Middelheim (Antwerpen, Belgium)
Protocol summary http://clinicaltrials.gov/ct/show/NCT00626990
NCT number NCT00626990
EudraCT 2006-001533-17
Financial Support Educational Grant