Study

EORTC-26053-22054-BTG-ROG

Phase III trial on concurrent and adjuvant temozolomide chemotherapy in non-1p/19q deleted anaplastic glioma. The CATNON intergroup trial.

Study documentation Back to result

Trial Status

Closed to Patient Entry

Dates

Date of activation: 03-Dec-2007
Date Step1 close: 16-Sep-2015
Date Step2 close: 06-Oct-2015

Data management at EORTC

Yes

Design

Phase 3
Randomized open label

Targeted Sample size

EORTC Groups: 550 - All Groups: 748

Treatment

Radiotherapy, Drug
Temozolomide

Study Staff

  • Martin J. van den Bent (Study Coordinator), Erasmus MC, Rotterdam
  • Carolina Fernandes (Clinical Operations Manager), EORTC Headquarters, Brussels
  • Vassilis Golfinopoulos (Clinical Research Physician), EORTC Headquarters, Brussels
  • Thierry Gorlia (Statistician), EORTC Headquarters, Brussels
  • Marie-Ange Lentz (Data Manager), EORTC Headquarters, Brussels
  • Sara Meloen (Pharmacovigilance Manager), EORTC Headquarters, Brussels
  • Miriam Presas (Junior RAM), EORTC Headquarters, Brussels
  • Nathalie Ropson (Regulatory Affairs Manager), EORTC Headquarters, Brussels
  • Nabila Sebti (Data Manager), EORTC Headquarters, Brussels

Type of cancer

  • Brain

Participating groups

  • EORTC Brain Tumor Group
  • EORTC Radiation Oncology Group
  • NCIC Clinical Trial Group
  • Radiation Therapy Oncology Group
  • Cancer Trials Support Unit
  • Cooperative Trials Group for Neuro-Oncology
  • University College of London

Recruiting centers

  • APHP Sorbonne Univ - Hopital la Pitie-Salpetriere (PARIS, France)
  • AUSL Bologna - Ospedale Bellaria (Bologna, Italy)
  • AZ Sint-Lucas & Volkskliniek (Gent, Belgium)
  • Akron City Hospital - Summa Health System (Akron, United States of America)
  • Alfred Hospital (Prahran, Australia)
  • Allan Blair Cancer Centre (Regina, Saskatchewan, Canada)
  • Altru Cancer Center (Grand Forks, United States of America)
  • Amsterdam UMC - Locatie AMC (Amsterdam, Netherlands)
  • Amsterdam UMC - locatie VUMC (Amsterdam, Netherlands)
  • Austin Health - Austin hospital (Heidelberg VIC, Australia)
  • Azienda Ospedaliera Città della Salute e della Scienza di Torino - Ospedale San Giovanni - Dipartimento Neuroscienze (Torino, Italy)
  • Barnes West County Hospital (Saint Louis, United States of America)
  • Brigham and Women's Hospital (Boston, United States of America)
  • CHRU de Nancy - Hopital Central (NANCY CEDEX, France)
  • Cadence Cancer Center in Warrenville (Warrenville, United States of America)
  • Cambridge University Hospital NHS - Addenbrookes Hospital (Cambridge, United Kingdom)
  • Cancer Care Center, Incorporated (Salem, United States of America)
  • Cancer Treatment Center (Wooster, United States of America)
  • Cancercare Manitoba (Winnipeg, Canada)
  • Carolinas Medical Center (Charlotte, United States of America)
  • Cedars-Sinai Medical Center (Los Angeles, United States of America)
  • Centre Antoine Lacassagne (NICE CEDEX 2, France)
  • Centre Eugene Marquis (RENNES CEDEX, France)
  • Centre Georges-Francois-Leclerc (DIJON CEDEX, France)
  • Centre Hospitalier de l'Université de Montreal - Hopital Notre-Dame (Montreal, Canada)
  • Clatterbridge Cancer Center - Wirral (Wirral, United Kingdom)
  • Cleveland Clinic Foundation (Cleveland, United States of America)
  • Cliniques Universitaires Saint-Luc (Brussels, Belgium)
  • Columbia University Medical Center (New York, United States of America)
  • Community Cancer Center Foundation (Normal, United States of America)
  • Dartmouth Hitchcock Medical Center (Lebanon, United States of America)
  • Derriford Hospital (Plymouth, United Kingdom)
  • Dixie Medical Center Regional Cancer Center (Saint George, United States of America)
  • Emory University (Atlanta, United States of America)
  • Erasmus MC (Rotterdam, Netherlands)
  • Flinders Medical Centre (Bedford Park, Australia)
  • Florida Hospital (Orlando, United States of America)
  • Gloucestershire Hospital NHS Foundation Trust - Cheltenham General Hospital (Cheltenham, United Kingdom)
  • Grand Hopital de Charleroi - Site Notre Dame (Charleroi, Belgium)
  • Gustave Roussy (VILLEJUIF CEDEX, France)
  • Guy s and St Thomas' NHS - Guy's Hospital (London, United Kingdom)
  • Haaglanden MC - locatie Antoniushove ( Leidschendam, Netherlands)
  • Henry Ford Hospital (Detroit, United States of America)
  • Highland Hospital (Rochester, United States of America)
  • Hopital de La Timone (APHM) (MARSEILLE, France)
  • Hopitaux universitaires de Geneve - HUG - site de Cluse-Roseraie (Geneve, Switzerland)
  • Hospital Clinic de Barcelona (Barcelona, Spain)
  • Hull and East Yorkshire Hospitals NHS Trust - Castle Hill Hospital (Cottingham, United Kingdom)
  • ICO Badalona - Hospital Germans Trias i Pujol (Institut Catala D'Oncologia) (Badalona - (Barcelona), Spain)
  • IRCCS - Istituto Neurologico Carlo Besta (Milano, Italy)
  • Illinois CancerCare-Peoria (Peoria, United States of America)
  • Imperial College Healthcare NHS Trust - Charing Cross Hospital (London, United Kingdom)
  • Instituut Verbeeten (Tilburg, Netherlands)
  • Intermountain Medical Center (Murray, United States of America)
  • Kirklin Clinic Acton Road (Birmingham, United States of America)
  • LDS Hospital (Salt Lake City, United States of America)
  • Lake University Ireland Cancer Center (Mentor, United States of America)
  • Lancashire Teaching Hospitals NHS Foundation Trust - Royal Preston Hospital (Preston, United Kingdom)
  • Leeds Teaching Hospitals NHS Trust - St. James's University Hospital (Leeds, United Kingdom)
  • Lehigh Valley Hospital (Allentown, United States of America)
  • London Regional Cancer Center (London, Canada)
  • Loyola University Medical Center (Maywood, United States of America)
  • Maastro Clinic - Maastricht Radiation Oncology (Maastricht, Netherlands)
  • Maidstone & Tunbridge Wells NHS Trust - Maidstone Hospital (Maidstone, United Kingdom)
  • Maine Medical Center (Scarborough, United States of America)
  • Massachussets General Hospital Cancer Center (Boston, United States of America)
  • Mayo Clinic (Rochester, United States of America)
  • Mayo Clinic in Florida (Jacksonville, United States of America)
  • McKay-Dee Hospital Center (Ogden, United States of America)
  • Medical University of South Carolina-CT services at Univ. Med Center (Charleston, United States of America)
  • Medizinische Hochschule Hannover (Hannover, Germany)
  • Methodist Hospital - Main location (Houston, United States of America)
  • NHS Greater Glasgow and Clyde - Beatson West of Scotland Cancer Centre - Gartnavel General Hospital (Glasgow, United Kingdom)
  • NHS Lothian - Western General Hospital (Edinburgh, United Kingdom)
  • Nebraska Medical Center (Omaha, United States of America)
  • Newcastle Hospitals NHS Trust - Freeman Hospital, Northern Centre For Cancer Care (Newcastle upon Tyne, United Kingdom)
  • Northwestern University Hospital (Chicago, United States of America)
  • Nottingham University Hospitals NHS Trust - City Hospital (Nottingham, United Kingdom)
  • OSF Saint Francis Medical Center (Peoria, United States of America)
  • OSF Saint Francis Radiation Oncology (Peoria, United States of America)
  • Ohio State University Medical Center (Columbus, United States of America)
  • Oncology Associates PC (Fort Wayne, United States of America)
  • Oxford University Hospitals NHS Trust - Churchill Hospital (Oxford, United Kingdom)
  • Parkview Hospital (Fort Wayne, United States of America)
  • Pekin Cancer Treatment Center (Pekin, United States of America)
  • Penn State M.S. Hershey Medical Center (Hershey, United States of America)
  • Piedmont Fayette Hospital (Fayetteville, United States of America)
  • Piedmont Hospital (Atlanta, United States of America)
  • Prince Of Wales Hospital (Randwick - Sydney, Australia)
  • Princess Alexandra Hospital - University Of Queensland (Woolloongabba, Brisbane, Australia)
  • Providence Regional Cancer Partnership (Everett, United States of America)
  • Radboud University Medical Center Nijmegen (Nijmegen, Netherlands)
  • Rapid City Regional Hospital (Rapid City, United States of America)
  • Royal Brisbane And Women's Hospital (Herston - Brisbane, Australia)
  • Royal Hobart Hospital (Hobart, Australia)
  • Royal Melbourne Hospital (Parkville, Australia)
  • Royal North Shore Hospital (St Leonards, Australia)
  • Royal Prince Alfred Hospital (Sydney, Australia)
  • S.B. Marmara Universitesi Pendik Egitim ve Arastirma Hastanesi (Istanbul, Turkey)
  • Saint Luke's University Hospital, Bethlehem Campus (Bethlehem, United States of America)
  • Saskatoon Cancer Centre (Saskatoon, Saskatchewan, Canada)
  • Sheffield Teaching Hospitals NHS Foundation Trust - Weston Park Hospital (Sheffield, United Kingdom)
  • Siouxland Regional Cancer Center (Sioux City, United States of America)
  • Sir Charles Gairdner Hospital (Nedlands, Australia)
  • Siteman Cancer Center-South County (St Louis, United States of America)
  • Siteman Cancer center- St. Louis (St Louis, United States of America)
  • Skagit Valley Hospital (Mount Vernon, United States of America)
  • Southwest General Health Center Ireland Cancer Center (Middleburg Heights, United States of America)
  • Spartanburg Regional Medical Center (Spartanburg, United States of America)
  • St Vincent'S Hospital (Fitzroy (melbourne), Australia)
  • Summa Barberton Hospital (Barberton, United States of America)
  • Summa Health Center at Lake Medina (Medina, United States of America)
  • Swedish Cancer Institute (Seattle, United States of America)
  • Tacoma General Hospital - Northwest CCOP (Tacoma, United States of America)
  • The Christie NHS Foundation Trust (Manchester, United Kingdom)
  • The University of Texas MD Anderson Cancer Center (Houston, United States of America)
  • Tom Baker Cancer Centre (Calgary, Canada)
  • Tri-Cities Cancer Center (Kennewick, United States of America)
  • U.Z. Leuven - Campus Gasthuisberg (Leuven, Belgium)
  • UCSF University of California San Francisco Medical Center-Mount Zion (San Francisco, United States of America)
  • UHB-Queen Elizabeth Medical Centre (Birmingham, United Kingdom)
  • UHHS - Westlake Medical Center (Westlake, United States of America)
  • UHHS-Chagrin Highlands Medical Center (Orange Village, United States of America)
  • UPMC - Heritage Valley Health System - The Medical Center (Beaver, United States of America)
  • UniversitaetsKlinikum Heidelberg - Head Hospital (Heidelberg, Germany)
  • UniversitaetsSpital Zurich (Zurich, Switzerland)
  • Universitaetsklinikum Bonn (Bonn, Germany)
  • Universitaetsklinikum Carl Gustav Carus (TUD) (Dresden, Germany)
  • Universitaetsklinikum Koeln (Koeln, Germany)
  • Universitaetsklinikum Leipzig-Klinik fuer Strahlentherapie und Radioonkologie (Leipzig, Germany)
  • Universitaetsklinikum Regensburg (Regensburg, Germany)
  • Universitaetsklinikum Tuebingen- Crona Kliniken (Tuebingen, Germany)
  • Universitair Ziekenhuis Brussel (Brussels, Belgium)
  • University Health Network - Oci / Princess Margaret Hospital (Toronto, Canada)
  • University Hospital Southampton NHS Foundation Trust - Southampton General Hospital (Southampton, United Kingdom)
  • University Hospitals Bristol NHS Foundation Trust - Bristol Haematology And Oncology Centre (Bristol, United Kingdom)
  • University Medical Center Groningen (Groningen, Netherlands)
  • University Of Kansas Cancer Center- (Kansas City, United States of America)
  • University of Alabama at Birmingham (Birmingham, United States of America)
  • University of Florida (Gainesville, United States of America)
  • University of Kentuky (Lexington, United States of America)
  • University of New Mexico, Cancer Care Alliance (Albuquerque, United States of America)
  • University of Oklahoma - Health Science Center (Oklahoma City, United States of America)
  • University of Rochester - James P. Wilmot Cancer Center (Rochester, United States of America)
  • University of Texas Medical Branch (Galveston, United States of America)
  • University of Texas Southwestern Medical Center (Dallas, United States of America)
  • University of Washington Medical Center (Seattle, United States of America)
  • University of Wisconsin Hospital and Clinics - Comprehensive Cancer Center (Madison, United States of America)
  • Upstate University Hospital (New York, United States of America)
  • Utah Valley Regional Medical Center (Provo, United States of America)
  • Via Christi Regional Medical Center (Wichita, United States of America)
  • Virginia Commonwealth University/Massey Cancer Center (Richmond, United States of America)
  • Waukesha Memorial Hospital (Waukesha, United States of America)
  • Wesley Medical Center (Wichita, United States of America)
  • Western Reserve University (Cleveland, United States of America)
  • Westmead Hospital - Crown Princess Mary Cancer Center (Westmead, Australia)
  • ZAS Middelheim (Antwerpen, Belgium)

Protocol summary

http://clinicaltrials.gov/study/NCT00626990

NCT number

NCT00626990

EudraCT

2006-001533-17