Radiation Therapy Quality Assurance (RTQA)

Research Groups

Restricted acces

Complex Dosimetry Check

A Complex Dosimetry Check (CDC) is required for each new protocol involving IMRT / SBRT / VMAT / TomoTherapy. It can be performed by two means:

  1. either a site orders a specific IMRT phantom (carrying films and TLDs), scans it, plans it, irradiates it and then sends it back for evaluation (end-to-end check), or
  2. the site irradiates its own in-house IMRT phantom, based on a provided plan, and sends the measurements and TPS dose files for evaluation.

CDC credentialing ensures that the institution has correctly implemented the advanced technique within their practice. This increases the likelihood that the quality of radiation treatment provided to EORTC trial patients is at the highest standard.

CDC Credentialing is granted for the combination of treatment planning system and algorithm, treatment unit and technique.  Currently, treatment units are distinguished as: Linac and Rotational. IMRT techniques are distinguished as Static (step and shoot), dynamic and rotational. These IMRT techniques are further subdivided into flattening filter free and flattened beams.

A successful CDC is valid for IMRT accreditation in a trial.

A repeat credentialing exercise for a new trial is required when either:

  • any of the combination parameters change
  • the gamma index criteria for a specific trial to which the institution wants to participate is not met
  • the disease site credentialed for is not deemed comparable (complexity of treatment) to that of the trial to which the institution wants to participate

Mailed Phantom Procedure

Third party phantoms for CDC accreditation may be necessary for specific studies. When necessary, sites wishing to participate in a trial will directly contact the provider of the service to arrange for delivery and re-sending of the irradiated phantom. Results provided by the third party will be forwarded to the EORTC and serve as the basis for credentialing.

Virtual Phantom Procedure

This procedure uses a “Virtual” phantom as opposed to a “real” phantom. The Virtual Phantom Procedure is very similar to patient QC procedures carried out for the treatment of complex techniques where a patient’s plan is transferred onto an IMRT QA phantom, recalculated and then irradiated according to plan. The delivered dose is then compared to the calculated dose to assess metrics such as DtA or the gamma index. In the context of an EORTC clinical trial, the plan transferred and recalculated is usually the same plan submitted for the Benchmark Case.

The measured and planned data are sent to EORTC for processing with acceptance criteria depending on the study characteristics, disease site and technique; a frequent criterion for acceptance is a 3 mm / 3 % gamma analysis with 95% compliance.

In general, the following data are required for a successful VPP:


DICOM-CT CT data set of in-house QA phantom
DICOM-RTDose 3D dose matrix of plan from TPS
Digital Format( according to TPS as identified below) All measurements and calculations in 2D or 3D that you have used for your QA analysis
All plan calculations from TPS in 2D or 3D used for the comparison measurements
Any format Description of phantom type, manufacture, normalization point and normalization method used for QA procedures.

Please indicate if the normalization method used is corrected for daily output fluctuations and if the normalization point is to 100% of the measured dose or 100% of the calculated dose


All the files are to be exported, zipped and submitted via the EORTC uploader at https://uploader.eortc.be/qart/

Note: our analysis can only be completed using the specific TPS file formats noted in the tables below.

Pinnacle Xio Preciplan Monaco Ergo++ Eclipse Cadplan
File extension .hea, .header .dcm, .txt .dcm, .txt .dcm .dcm, .hdr .dcm .ef
, .df
Tomo Oncentra Theraplan Helax Plato Corvus Optirad
.dcm .dcm, .header .dcm .dcm .dcm .dcm .tif .dcm


Pinnacle Xio Preciplan Monaco Ergo++ Eclipse Cadplan
.dcm .dcm, .hea, .header dcm       .dcm  
Tomo Oncentra Theraplan Helax Plato Corvus Optirad
.dcm .dcm, .header .dcm          


Delta 4 Varian aS portal Image Elekta EPID Scanned films Omnipro PTW 729 2D-array Sun nuclear MapCHECK IBA MatriXX
.dcm .dbf .dcm .jpg, .his .rv4, .hdr, 48 bit .tif, .tiff  .opg .mcc  .txt  .opg 

Note: For Siemens EPID import no specific file format is required


The Virtual Phantom Procedure is performed over a variety of datasets in different formats on multiple software platforms. We would like to acknowledge the sponsorship of the following companies who kindly provided us their software for the purpose of analysis:

  • Scandidos, for kindly providing us the software to analyze Delta4 phantom measurements

Find us

Avenue Emmanuel Mounier, 83/11
Brussels 1200

Contact us

Follow us