EORTC abstracts selected at ASCO

It is a tremendous year for EORTC at the 2019 ASCO Annual Meeting in Chicago, USA from May 31 to June 4.

In total, 12 EORTC abstracts have been selected: 6 oral presentations, 3 posters discussions and 3 posters (including one collaboration) of which 2 have been selected for best of ASCO 2019 meetings!

6 oral presentations

• Second interim and 1st molecular analysis of the EORTC randomized phase III intergroup CATNON trial on concurrent and adjuvant temozolomide in anaplastic glioma without 1p/19q codeletion.

Martin J. Van Den Bent, Sara Erridge, Michael A. Vogelbaum, Anna K. Nowak, Marc Sanson, Alba Ariela Brandes, Wolfgang Wick, Paul M. Clement, Jean-Francois Baurain, Warren P. Mason, Helen Wheeler, Michael Weller, Kenneth D. Aldape, Pieter Wesseling, Johan M. Kros, Mircea Tesileanu, Vassilis Golfinopoulos, Thierry Gorlia, Brigitta G. Baumert, Pim French
Abstract number: #2000
Speaker: M. Van Den Bent
Date: 03.06.2019 – Lecture Time: 13:15 – Location: S102

This abstract has been selected for best of ASCO 2019 meetings

• Decreased fracture rate by mandating bone protecting agents in the EORTC 1333/PEACE III trial comparing enzalutamide and Ra223 versus enzalutamide alone; an interim safety analysis.

Bertrand F. Tombal, Yohann Loriot, Fred Saad, Raymond S. McDermott, Tony Elliott, Alejo Rodriguez Vida, Franco Nole, Beatrice Fournier, Laurence Collette, Silke Gillessen
Abstract number: #5007
Speaker: B. Tombal
Date: 31.05.2019 – Lecture Time: 14:45 – Location: Arie Crown Theater

This abstract has been selected for best of ASCO 2019 meetings

• Trabectedin for recurrent WHO grade II or III meningioma: a randomized phase II study of the EORTC Brain Tumor Group (EORTC-1320-BTG).

Matthias Preusser, Antonio Silvani, Emilie Le Rhun, Riccardo Soffietti, Giuseppe Lombardi, Juan M. Sepúlveda, Petter Brandal, Ronald Philip Beaney, Alice Bonneville-Levard, Veronique Lorgis, Elodie Vauleon, Jacqueline Bromberg, Sara Erridge, Alison Cameron, Christine Marosi, Vassilis Golfinopoulos, Thierry Gorlia, Michael Weller, Wolfgang Wick
Abstract number:  #2007
Speaker: M. Preusser
Date: 03.06.2019 – Lecture Time: 13:15 – Location: S102

• Results from neoadjuvant chemotherapy followed by surgery compared to chemoradiation for stage ib2-iib cervical cancer, EORTC 55994

Gemma Kenter, Stefano Greggi, Ignace Vergote, Dionyssios Katsaros, Juliusz Kobierski, Leon Massuger, H. C. van Doorn, Fabio Landoni, Jacobus Van Der Velden, Nicholas Simon Reed, Corneel Coens, Iske van Luijk, P. B. Ottevanger, Antonio Casado
Abstract number:  #5503
Speaker: G. Kenter
Date: 03.06.2019 – Lecture Time: 13:15 – Location: S406

• STRASS (EORTC 62092): A phase III randomized study of preoperative radiotherapy plus surgery versus surgery alone for patients with retroperitoneal sarcoma

Sylvie Bonvalot, Alessandro Gronchi, Cecile Le Pechoux, Caroll Swallow, Dirk C Strauss, Pierre Meeus, Frits van Coevorden, Stephan Stoldt, Eberhard Stoeckle, Piotr Rutkowski, Claudia Sangalli, Charles Honoré, Marco Rastrelli, Chandrajit Raut, Peter Chung, Marco Fiore, Saskia Litiere, Sandrine Marreaud, Hans Gelderblom, Rick L.M. Haas
Abstract number: #11001
Speaker: S. Bonvalot
Date: 03.06.2019 – Lecture Time: 08:00 – 11:00 – Location: E450

• Activity and safety of cabozantinib in patients with gastrointestinal stromal tumor after failure of imatinib and sunitinib. EORTC Phase 2 trial 1317 CaboGIST.

Patrick Schöffski, Olivier Mir, Bernd Kasper, Zsuzsanna Papai, Jean-Yves Blay, Antoine Italiano, Charlotte Benson, Katerina Kopeckova, Nasim Ali, Palma Dileo, Axel Le Cesne, Franka Menge, Sophie Cousin, Celine Charon-Barra, Agnieszka Wozniak, Sandrine Marreaud, Saskia Litiere, Axelle Nzokirantevye, Hans Gelderblom
Abstract number: #11006
Speaker: P. Schöffski
Date: 03.06.2019 – Lecture Time: 08:00 – 11:00 – Location: E450

3 poster discussions

• Prognostic and predictive value of an immune-related adverse event among stage III melanoma patients included in the EORTC 1325/KEYNOTE-054 pembrolizumab vs placebo trial

Alexander M. M. Eggermont, Michal Kicinski, Christian U. Blank, Mario Mandalà, Georgina V. Long, Victoria Atkinson, Stéphane Dalle, Andrew Mark Haydon, Mikhail Lichinitser, Muhammad Khattak, Matteo S. Carlino, Shahneen Kaur Sandhu, Susana Puig, Paolo Antonio Ascierto, Clemens Krepler, Nageatte Ibrahim, Sandrine Marreaud, Alexander Christopher Jonathan Van Akkooi, Caroline Robert, Stefan Suciu
Abstract number: #2517
Poster Presenter: A. Eggermont
Date: 01.06.2019 – Lecture Time: 13:15 -14:45 – Location: Hall D1

• Ipilimumab vs placebo after complete resection of stage III melanoma: long-term follow-up results the EORTC 18071 double-blind phase 3 randomized trial.

Alexander M. M. Eggermont, Vanna Chiarion-Sileni, Jean-Jacques Grob, Reinhard Dummer, Jedd D. Wolchok, Henrik Schmidt, Omid Hamid, Caroline Robert, Paolo Antonio Ascierto, Jon M. Richards, Celeste Lebbe, Virginia Ferraresi, Michael Smylie, Jeffrey S. Weber, Michele Maio, Fareeda Hosein, Veerle de Pril, Michal Kicinski, Stefan Suciu, Alessandro Testori
Abstract number: #2512
Poster Presenter: A. Eggermont
Date: 01.06.2019 – Lecture Time: 13:15 -14:45 – Location: Hall D1

• Randomised phase II trial of imatinib alternating with regorafenib vs imatinib alone for the first line treatment of metastatic gastrointestinal stromal tumor (GIST)

Desmond Yip. John Zalcberg. Jean-Yves Blay. Mikael Eriksson. David Espinoza. Tim Price. Sandrine Marreaud. Antoine Italiano. Neeltje Steeghs. Kjetil Boye. Craig Underhill. Sayeda Naher. Laura de Meulemeester. Martijn Oostendorp. Val Gebski. John Simes. Hans Gelderblom. Heikki Joensuu
Abstract number: #11023
Poster Presenter: D. Yip
Date: 01.06.2019 – Lecture Time: 15:00 – 16:30 – Location: S404

2 posters

• EORTC 1709/CCTG CE.8: A phase III trial of marizomib in combination with standard temozolomide-based radiochemotherapy versus standard temozolomide-based radiochemotherapy alone in patients with newly diagnosed glioblastoma.

Patrick Roth, Jaap C. Reijneveld, Thierry Gorlia, Frederic Dhermain, Filip Yves Francine Leon De Vos, Maureen Vanlancker, Christopher J. O’Callaghan, Emilie Le Rhun, Martin J. Van Den Bent, Warren P. Mason, Michael Weller
Abstract number: TPS2072
Poster Presenter: P. Roth
Date: 02.06.2019 – Lecture Time: 8:00 – 11:00 – Location: Hall A

• Molecular genetic, host-derived and clinical determinants of long-term survival in glioblastoma – first results from the ETERNITY study (EORTC 1419).

Michael Weller, Guido Reifenberger, Emilie Le Rhun, Jennifer Leigh Clarke, Riccardo Soffietti, Antje Wick, Olivier L. Chinot, Francois Ducray, Peter Hau, Kerrie Leanne McDonald, Christine Marosi, Oliver Schnell, Andreas Felix Hottinger, Jaap C. Reijneveld, Giuseppe Lombardi, Patrick Y. Wen, Martin Klein, Thierry Gorlia, Joerg Felsberg, Caroline Hertler, for the BTFC Consortium on Long-term Survival with Glioblastoma & the EORTC Brain Tumor Group
Abstract number: #2056
Poster Presenter: M. Weller
Date: 02.06.2019 – Lecture Time: 08:00-11:00 – Location: Hall A

Abstract with EORTC collaboration

• TMB Standardization by Alignment to Reference Standards: Phase 2 of the Friends of Cancer Research TMB Harmonization Project.

Diana M. Merino, Lisa McShane, Matt Butler, Vincent Anthony Funari, Matthew David Hellmann, Ruchi Chaudhary, Shu-Jen Chen, Wangjuh Sting Chen, Jeffrey M. Conroy, David Fabrizio, Laura E MacConaill, Aparna Pallavajjala, Arnaud Papin, Mark Sausen, Victor J Weigman, Mingchao Xie, Ahmet Zehir, Chen Zhao, Paul M. Williams, Friends of Cancer Research TMB Harmonization Team
Abstract number: #2624
Poster Presenter: D. Merino
Date: 01.06.2019 – Lecture Time: 8:00 – 11:00 – Location: Hall A

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