Recruiting

Date of activation: 05-Oct-2020

Yes

Phase 3
Randomized open label

All Groups: 240

Surgery, Drug
Dacarbazine, Doxorubicin, Epirubicin, Ifosfamide

• Alessandro Gronchi (Study Coordinator), IRCCS - Fondazione Istituto Nazionale dei Tumori, Milano
• Winan Van Houdt (Study Coordinator), The Netherlands Cancer Institute-Antoni Van Leeuwenhoekziekenhuis, Amsterdam
• Amelie Baudhuin (Clinical Operations Assistant), EORTC Headquarters, Brussels
• Jose Casas (TR Scientist), EORTC Headquarters, Brussels
• Corneel Coens (Statistician), EORTC Headquarters, Brussels
• Ilse Coppens (Clinical Operations Assistant), EORTC Headquarters, Brussels
• Benedicte Demeulder (Project Manager), EORTC Headquarters, Brussels
• Amaya Gonzalez (Junior Clinical Operations Manager, Clinical Research Associate/Monitor), EORTC Headquarters, Brussels
• Piet Gutscoven (Data Manager), EORTC Headquarters, Brussels
• Ana Joaquim (Project Physician), EORTC Headquarters, Brussels
• Ryosuke Kita (Medical Fellow), EORTC Headquarters, Brussels
• Stephanie Kromar (Senior Regulatory Affairs Manager), EORTC Headquarters, Brussels
• Alexandra Latteux (Clinical Operations Assistant), EORTC Headquarters, Brussels
• Stephane Lejeune (International Affairs and Policies Manager), EORTC Headquarters, Brussels
• Niels Lema (Clinical Data Expert), EORTC Headquarters, Brussels
• Saskia Litiere (Statistician), EORTC Headquarters, Brussels
• Juliette Ly (Project Manager), EORTC Headquarters, Brussels
• Eleni Mandila (Regulatory Affairs Administrator), EORTC Headquarters, Brussels
• Sandrine Marreaud (Clinical Research Physician), EORTC Headquarters, Brussels
• Camila Matiollo (Data Manager), EORTC Headquarters, Brussels
• Zara Nasir (Pharmacovigilance Manager), EORTC Headquarters, Brussels
• David Ndah Aki (Clinical Operations Manager), EORTC Headquarters, Brussels
• Axelle Nzokirantevye (Data Manager), EORTC Headquarters, Brussels
• Felix Oppong (Statistician), EORTC Headquarters, Brussels
• Madeline Pe (QoL Specialist), EORTC Headquarters, Brussels
• Sandrine Rivrain (Pharmacovigilance Manager), EORTC Headquarters, Brussels
• Zineb Wadid (Lead CRA), EORTC Headquarters, Brussels
• Xiao Mang Zhou (Junior RAM), EORTC Headquarters, Brussels
• Christine de Balincourt (Lead CRA), EORTC Headquarters, Brussels

• Soft Tissue and Bone Sarcoma

• EORTC Soft Tissue and Bone Sarcoma Group
• Japan Clinical Oncology Group
• Canadian Cancer Trials Group
• Australia and New Zealand Sarcoma Association
• ECOG-ACRIN

• Aichi Cancer Center Hospital (Aichi, Japan)
• BC Cancer (Britisch Columbia Cancer Agency) (Vancouver, Canada)
• Bank Of Cyprus Oncology Centre (Strovolos - Nicosia, Cyprus)
• Cancer Institute Hospital of JFCR (Tokyo, Japan)
• Carilion Roanoke Memorial Hospital (Roanoke, United States of America)
• Centre Leon Berard (Lyon, France)
• Centro Di Riferimento Oncologico (Aviano, Italy)
• Chris O'Brien Lifehouse (Camperdown NSW , Australia)
• City Of Hope National Medical Center (Duarte, United States of America)
• Clatterbridge Cancer Center - Wirral (Wirral, United Kingdom)
• Dana-Farber Cancer Institute & Harvard Medical School (Boston, United States of America)
• Duke University Medical Center (Durham, United States of America)
• Emory University Hospital Midtown (Atlanta, United States of America)
• Fox Chase Medical Center (Philadelphia, United States of America)
• Fred Hutchinson Cancer Center- South Lake Union (Seattle, United States of America)
• Fred Hutchison Seattle Cancer Care Alliance (Seattle, United States of America)
• Froedtert and the Medical College of Wisconsin (Milwaukee, United States of America)
• Gustave Roussy (VILLEJUIF CEDEX, France)
• H. Lee Moffitt Cancer Center Magnolia Campus (Tampa (FL), United States of America)
• Herlev Hospital - University Copenhagen (Herlev, Denmark)
• Hopital Maisonneuve Rosemont (Montreal,quebec, Canada)
• Hopitaux Universitaires de Strasbourg - Hautepierre (Strasbourg Cedex 1, France)
• Hospital De La Santa Creu I Sant Pau (Barcelona, Spain)
• Hospital General Universitario Gregorio Maranon (Madrid, Spain)
• Hospital Universitario San Carlos (Madrid, Spain)
• Hospital of the University of Pennsylvania (Philadelphia, United States of America)
• ICO Badalona - Hospital Germans Trias i Pujol (Institut Catala D'Oncologia) (Badalona - (Barcelona), Spain)
• IRCCS - Fondazione Istituto Nazionale dei Tumori (Milano, Italy)
• IRCCS - Fondazione Piemonte Inst di Candiolo (Candiolo (Torino), Italy)
• IRCCS - Istituto Oncologico Veneto (Padova, Italy)
• IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori" (Meldola, Italy)
• Institut Curie- Hopital de Paris (PARIS CEDEX 05, France)
• Institut du Cancer de Montpellier (MONTPELLIER CEDEX 5, France)
• Istituto Clinico Humanitas (Rozzano, Milano, Italy)
• Istituto Europeo di Oncologia (Milano, Italy)
• Jichi Medical University Saitama Medical Center (Saitama, Japan)
• Johns Hopkins Medicine - Kimmel Comprehensive Cancer Center (Baltimore, United States of America)
• Kanagawa Cancer Center (Kanagawa, Japan)
• Kansas University Cancer center (Westwood, United States of America)
• Kyushu University Hospital (Fukuoka, Japan)
• LSU Health Baton Rouge North Clinic (Baton Rouge, United States of America)
• Leeds Teaching Hospitals NHS Trust - St. James's University Hospital (Leeds, United Kingdom)
• Leiden University Medical Centre (Leiden, Netherlands)
• London Regional Cancer Center (London, Canada)
• Maria Sklodowska-Curie National Research Institute of Oncology (Warsaw, Poland)
• Masaryk Memorial Cancer Institute (Brno, Czech Republic)
• Mayo Clinic (Rochester, United States of America)
• Mayo Clinic Hospital in Arizona (Phoenix, United States of America)
• Mayo Clinic in Florida (Jacksonville, United States of America)
• McGill University Health Centre - Montreal General Hospital (Montreal, Canada)
• Moffit Cancer Center - International Plazza (Tampa, United States of America)
• Moffit cancer Center - McKinley Campus (Tampa, United States of America)
• Mount Sinai Hospital (Toronto, Ontario, Canada)
• NHS Greater Glasgow and Clyde - Beatson West of Scotland Cancer Centre - Gartnavel General Hospital (Glasgow, United Kingdom)
• Nagoya University Hospital (Nagoya, Japan)
• Narodny Onkologicky Ustav - Bratislava (Bratislava, Slovakia)
• National Cancer Center - Hospital Tokyo (Tokyo, Japan)
• Nebraska Medical Center (Omaha, United States of America)
• Nebraska Medicine - Bellevue (bellevue, United States of America)
• Nebraska Medicine - Village Pointe (Omaha, United States of America)
• Niigata University Medical & Dental Hospital (Niigata-Shi, Japan)
• Nottingham University Hospitals NHS Trust - City Hospital (Nottingham, United Kingdom)
• Ohio State University Medical Center (Columbus, United States of America)
• Okayama University Hospital (Okayama, Japan)
• Oregon Health & Science Univ (Portland, United States of America)
• Osaka International cancer Institute (Chuo-Ku Osaka, Japan)
• Our Lady of The Lake Physicians Group (Baton Rouge, United States of America)
• Our Lady of the Lake Hospital (Baton Rouge, United States of America)
• Oxford University Hospitals NHS Trust - Churchill Hospital (Oxford, United Kingdom)
• Peter Maccallum Cancer Institute (Melbourne, Australia)
• Policlinico Universitario Campus Bio-Medico- Oncology Center (Roma, Italy)
• Princess Alexandra Hospital - University Of Queensland (Woolloongabba, Brisbane, Australia)
• Radboud University Medical Center Nijmegen (Nijmegen, Netherlands)
• Region Midtjylland - Aarhus University Hospital-Skejby (Aarhus, Denmark)
• Robert H. Lurie Comprehensive Cancer Center/ Northwestern Univ Feinberg School of Medicine (Chicago, United States of America)
• Roswell Park Cancer Institute (Buffalo, United States of America)
• Royal Marsden Hospital - Chelsea, London (London, United Kingdom)
• Sanford Bismarck Medical Center (Bismarck, United States of America)
• Sanford Broadway Medical Center (Fargo, United States of America)
• Sanford Cancer Center Oncology Clinic (Sioux Falls, United States of America)
• Sanford Joe Lueken Cancer center (Bemidji, United States of America)
• Sanford Roger Maris Cancer Center (Fargo, United States of America)
• Sanford USD Medical Center Sioux Falls (Sioux Falls, United States of America)
• Siteman Cancer Center - Barnes Jewish Hosp. (Saint Louis, United States of America)
• Siteman Cancer Center-West St Louis (Creve Coeur, United States of America)
• Siteman Cancer center- South St Louis County (St Louis, United States of America)
• Smilow Cancer Hospital Long Ridge (Stamford, United States of America)
• Smilow Cancer Hospital- Greenwich (Greenwich, United States of America)
• Smilow Cancer Hospital-Derby Care Center (Derby, United States of America)
• Smilow Cancer Hospital-Fairfield (Fairfield, United States of America)
• Smilow Cancer Hospital-Glastonbury (Glastonbury, United States of America)
• Smilow Cancer Hospital-Guilford (Guilford, United States of America)
• Smilow Cancer Hospital-North Haven (North Haven, United States of America)
• Smilow Cancer Hospital-Torrington (Torrington, United States of America)
• Smilow Cancer Hospital-Trumbull (Trumbull, United States of America)
• Smilow Cancer Hospital-Waterbury (Waterbury, United States of America)
• Smilow Cancer Hospital-Waterford (Waterford, United States of America)
• Smilow Cancer Hospital-Westerly (Westerly, United States of America)
• St. Francis Cancer Center (Hartford, United States of America)
• The Netherlands Cancer Institute-Antoni Van Leeuwenhoekziekenhuis (Amsterdam, Netherlands)
• The Ottawa Hospital - General Campus (Ottawa, Canada)
• The University of Texas MD Anderson Cancer Center (Houston, United States of America)
• Thomas Jefferson University Hospital-Jefferson Heart Institute (Philadelphia, United States of America)
• Tohoku University Hospital (Sendai Miyagi, Japan)
• UCHealth University Colorado Hospital (Colorado , United States of America)
• UHB-Queen Elizabeth Medical Centre (Birmingham, United Kingdom)
• UPMC Hillman Cancer Center (Pittsburgh, United States of America)
• UniversitaetsMedizin Mannheim (Mannheim, Germany)
• Universitaetsklinikum Carl Gustav Carus (TUD) (Dresden, Germany)
• Universitaetsmedizin Goettingen - Georg-August Universitaet (Goettingen, Germany)
• University Of Kansas Cancer Center- (Kansas City, United States of America)
• University Of Utah - Huntsman Cancer Institute (Salt Lake City, United States of America)
• University of California at Irvine (Orange, United States of America)
• University of Illinois Hospital (Chicago, United States of America)
• University of Kansas Cancer Center - Overland Park (Overland Park, United States of America)
• University of Michigan - Rogel Cancer Center (Ann Arbor, United States of America)
• University of Oklahoma - Health Science Center (Oklahoma City, United States of America)
• University of Rochester - James P. Wilmot Cancer Center (Rochester, United States of America)
• University of Washington Medical Center (Seattle, United States of America)
• VCU Community Memorial Health Center (South Hill, United States of America)
• VCU Massey cancer Center Stony Point (Richmond, United States of America)
• VCU Massey cancer Center at Hanover Medical park (Mechanicsville, United States of America)
• Virginia Commonwealth University/Massey Cancer Center (Richmond, United States of America)
• Yale University School Of Medicine (New Haven, United States of America)
• Yokohama City University Hospital (Kanagawa, Japan)

• AHN- Saint Vincent (Erie, United States of America)
• AHN-Allegheny General Hospital (Pittsburgh, United States of America)
• AHN-Allegheny Valley Hospital (Natrona Heights, United States of America)
• AHN-Forbes Hospital (Monroeville, United States of America)
• AHN-Jefferson Hospital (Jefferson Hills, United States of America)
• AHN-West Penn Hospital (Pittsburgh, United States of America)
• AHN-Wexford Hospital (Wexford, United States of America)
• Dartmouth Hitchcock Medical Center (Lebanon, United States of America)
• Indiana University Medical Center (Indianapolis, United States of America)
• Marshfield Medical Center-EC Cancer Center (Eau Claire, United States of America)
• Marshfield Medical Center-Marshfield (Marshfield, United States of America)
• Marshfield Medical Center-Minocqua (Minocqua, United States of America)
• Marshfield Medical Center-Rice Lake (Rice Lake, United States of America)
• Marshfield Medical Center-River Region at Stevens Point (Stevens Point, United States of America)
• Marshfield Medical Center-Weston (Weston, United States of America)
• Newcastle Hospitals NHS Trust - Freeman Hospital, Northern Centre For Cancer Care (Newcastle upon Tyne, United Kingdom)
• Rutgers Cancer Institute New Jersey (New Brunswick, United States of America)
• Stony Brook University Hospital (New York, United States of America)
• University College Hospital (London, United Kingdom)
• University Medical Center Groningen (Groningen, Netherlands)
• University of Louisville James Graham Brown Cancer Center (Louisville, United States of America)
• Vanderbilt University Medical Center (Nashville, United States of America)

http://clinicaltrials.gov/study/NCT04031677

NCT04031677

2019-003543-30