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A randomised phase III trial with a PET response adapted design comparing ABVD +/- ISRT with A2VD +/- ISRT in patients with previously untreated stage IA/IIA Hodgkin lymphoma.

Study documentation

Trial Status Recruiting
Dates Date of activation: 01-Mar-2024
Data management at EORTC No
Design Phase 3
Randomized open label
Treatment Drug
Bleomycin, Dacarbazine, Doxorubicin, Vinblastine, Brentuximab vedotin
Study Staff Martin Hutchings (Study Coordinator) , Rigshospitalet, Copenhagen
Amelie Baudhuin (Clinical Operations Assistant) , EORTC Headquarters, Brussels
Emanuel Buhrer (Project Physician) , EORTC Headquarters, Brussels
Benedicte Demeulder (Project Manager) , EORTC Headquarters, Brussels
Catherine Fortpied (Statistician) , EORTC Headquarters, Brussels
Leslie Herman (Regulatory Affairs Manager) , EORTC Headquarters, Brussels
Juliette Ly (Project Manager) , EORTC Headquarters, Brussels
Nathalie Ropson (Regulatory Affairs Manager) , EORTC Headquarters, Brussels
Ward Sents (Clinical Scientist) , EORTC Headquarters, Brussels
Jelle Stans (Regulatory Affairs Manager) , EORTC Headquarters, Brussels
Bette Stofs (Pharmacovigilance Manager) , EORTC Headquarters, Brussels
Sanne Tonino (Study Co-Coordinator) , Amsterdam UMC - Locatie AMC, Amsterdam
Sofie Verschueren (Clinical Operations Manager) , EORTC Headquarters, Brussels
Type of cancer Hodgkins Disease
Participating groups EORTC Lymphoma Group
University College of London
Recruiting centers AZ Delta - Campus Rumbeke (Roeselare, Belgium)
Hospital Del Mar (Barcelona, Spain)
Centers to be activated Amsterdam UMC - Locatie AMC (Amsterdam, Netherlands)
Amsterdam UMC - locatie VUMC (Amsterdam, Netherlands)
CHU Site Sainte-Elisabeth-UCL Namur (Namur, Belgium)
Complejo Hospitalario de Navarra (Pamplona, Spain)
Haaglanden MC - locatie Antoniushove ( Leidschendam, Netherlands)
ICO L’Hospitalet - Hospital Duran i Reynals (Institut Catala D'Oncologia) (L' Hospitalet De Llobregat, Spain)
Instituto Portugues de Oncologia de Lisboa Francisco Gentil – EPE (Lisboa, Portugal)
Narodny Onkologicky Ustav - Bratislava (Bratislava, Slovakia)
Radboud University Medical Center Nijmegen (Nijmegen, Netherlands)
Region Midtjylland - Aarhus University Hospital-Skejby (Aarhus, Denmark)
Reinier De Graaf Gasthuis (Delft, Netherlands)
Rigshospitalet (Copenhagen, Denmark)
U.Z. Leuven - Campus Gasthuisberg (Leuven, Belgium)
Universitair Ziekenhuis Antwerpen (Edegem, Belgium)
University Medical Center Groningen (Groningen, Netherlands)
ZNA CADIX (Antwerpen, Belgium)
Protocol summary
NCT number NCT04685616
EudraCT 2020-005160-65
Financial Support Educational Grant