EORTC-1913-LYMG

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A randomised phase III trial with a PET response adapted design comparing ABVD +/- ISRT with A2VD +/- ISRT in patients with previously untreated stage IA/IIA Hodgkin lymphoma.

Study documentation

Trial Status	Recruiting
Dates	Date of activation: 01-Mar-2024
Data management at EORTC	No
Design	Phase 3 Randomized open label
Treatment	Drug Bleomycin, Dacarbazine, Doxorubicin, Vinblastine, Brentuximab vedotin
Study Staff	Martin Hutchings (Study Coordinator) , Rigshospitalet, Copenhagen Amelie Baudhuin (Clinical Operations Assistant) , EORTC Headquarters, Brussels Emanuel Buhrer (Project Physician) , EORTC Headquarters, Brussels Benedicte Demeulder (Project Manager) , EORTC Headquarters, Brussels Catherine Fortpied (Statistician) , EORTC Headquarters, Brussels Leslie Herman (Regulatory Affairs Manager) , EORTC Headquarters, Brussels Juliette Ly (Project Manager) , EORTC Headquarters, Brussels Nathalie Ropson (Regulatory Affairs Manager) , EORTC Headquarters, Brussels Ward Sents (Clinical Scientist) , EORTC Headquarters, Brussels Jelle Stans (Regulatory Affairs Manager) , EORTC Headquarters, Brussels Bette Stofs (Pharmacovigilance Manager) , EORTC Headquarters, Brussels Sanne Tonino (Study Co-Coordinator) , Amsterdam UMC - Locatie AMC, Amsterdam Sofie Verschueren (Clinical Operations Manager) , EORTC Headquarters, Brussels
Type of cancer	Hodgkins Disease
Participating groups	EORTC Lymphoma Group University College of London
Recruiting centers	AZ Delta - Campus Rumbeke (Roeselare, Belgium) Hospital Del Mar (Barcelona, Spain)
Centers to be activated	Amsterdam UMC - Locatie AMC (Amsterdam, Netherlands) Amsterdam UMC - locatie VUMC (Amsterdam, Netherlands) CHU Site Sainte-Elisabeth-UCL Namur (Namur, Belgium) Complejo Hospitalario de Navarra (Pamplona, Spain) Haaglanden MC - locatie Antoniushove ( Leidschendam, Netherlands) ICO L’Hospitalet - Hospital Duran i Reynals (Institut Catala D'Oncologia) (L' Hospitalet De Llobregat, Spain) Instituto Portugues de Oncologia de Lisboa Francisco Gentil – EPE (Lisboa, Portugal) Narodny Onkologicky Ustav - Bratislava (Bratislava, Slovakia) Radboud University Medical Center Nijmegen (Nijmegen, Netherlands) Region Midtjylland - Aarhus University Hospital-Skejby (Aarhus, Denmark) Reinier De Graaf Gasthuis (Delft, Netherlands) Rigshospitalet (Copenhagen, Denmark) U.Z. Leuven - Campus Gasthuisberg (Leuven, Belgium) Universitair Ziekenhuis Antwerpen (Edegem, Belgium) University Medical Center Groningen (Groningen, Netherlands) ZNA CADIX (Antwerpen, Belgium)
Protocol summary	http://clinicaltrials.gov/study/NCT04685616
NCT number	NCT04685616
EudraCT	2020-005160-65
Financial Support	Educational Grant