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A phase III randomized study of preoperative radiotherapy plus surgery versus surgery alone for patients with Retroperitoneal sarcomas (RPS) - STRASS

Study documentation

Trial Status LT-FU ongoing
Dates Date of activation: 16-Jan-2012
Date Step1 close: 11-Apr-2017
Data management at EORTC Yes
Design Phase 3
Randomized open label
Targeted Sample size EORTC Groups: 256 - All Groups: 256
Treatment Radiotherapy, Surgery
Study Staff Sylvie Bonvalot (Study Coordinator) , Institut Curie- Hopital de Paris, PARIS CEDEX 05
Rick Haas (Study Coordinator) , The Netherlands Cancer Institute-Antoni Van Leeuwenhoekziekenhuis, Amsterdam
Enrico Clementel (QART Manager) , EORTC Headquarters, Brussels
Laura De Meulemeester (Senior Clinical Operations Manager) , EORTC Headquarters, Brussels
Terry Desmae (TR Manager) , EORTC Headquarters, Brussels
Stephanie Kromar (Regulatory Affairs Manager) , EORTC Headquarters, Brussels
Saskia Litiere (Statistician) , EORTC Headquarters, Brussels
Sandrine Marreaud (Clinical Research Physician) , EORTC Headquarters, Brussels
Zara Nasir (Pharmacovigilance Manager) , EORTC Headquarters, Brussels
Axelle Nzokirantevye (Data Manager) , EORTC Headquarters, Brussels
Sandrine Rivrain (Pharmacovigilance Manager) , EORTC Headquarters, Brussels
Type of cancer Soft Tissue and Bone Sarcoma
Participating groups EORTC Radiation Oncology Group
EORTC Soft Tissue and Bone Sarcoma Group
Recruiting centers CHU de Toulouse - Institut Claudius Regaud - IUCT oncopole (TOULOUSE CEDEX 9, France)
Centre Hospitalier de l'Université de Montreal - Hopital Notre-Dame (Montreal, Canada)
Centre Leon Berard (Lyon, France)
Centro Di Riferimento Oncologico (Aviano, Italy)
Dana-Farber Cancer Institute & Harvard Medical School (Boston, United States of America)
Gustave Roussy (VILLEJUIF CEDEX, France)
Herlev Hospital - University Copenhagen (Herlev, Denmark)
Hospital Universitari Vall d’Hebron -Vall d'Hebron Institut Oncologia (Barcelona, Spain)
Hospital Universitario San Carlos (Madrid, Spain)
IRCCS - Fondazione Istituto Nazionale dei Tumori (Milano, Italy)
IRCCS - Istituto Oncologico Veneto (Padova, Italy)
Institut Bergonie (Bordeaux, France)
Institut Curie- Hopital de Paris (PARIS CEDEX 05, France)
Institut Jules Bordet (Anderlecht, Belgium)
Istituto Clinico Humanitas (Rozzano, Milano, Italy)
Karolinska University Hospital, location Solna (Stockholm Solna, Sweden)
Klinikum Rechts der isar Der Technische Universitaet Muenchen - Klinikum Rechts Der Isar (Muenchen, Germany)
Leeds Teaching Hospitals NHS Trust - St. James's University Hospital (Leeds, United Kingdom)
Leiden University Medical Centre (Leiden, Netherlands)
Ludwig-Maximilians-Universitaet Muenchen - Campus Grosshadern (Muenchen, Germany)
Mount Sinai Hospital (Toronto, Ontario, Canada)
NHS Lothian - Western General Hospital (Edinburgh, United Kingdom)
Newcastle Hospitals NHS Trust - Freeman Hospital, Northern Centre For Cancer Care (Newcastle upon Tyne, United Kingdom)
Nottingham University Hospitals NHS Trust - City Hospital (Nottingham, United Kingdom)
Oslo University Hospital - Radiumhospitalet (Oslo, Norway)
Radboud University Medical Center Nijmegen (Nijmegen, Netherlands)
Royal Marsden Hospital - Chelsea, London (London, United Kingdom)
Sheffield Teaching Hospitals NHS Foundation Trust - Weston Park Hospital (Sheffield, United Kingdom)
The Christie NHS Foundation Trust (Manchester, United Kingdom)
The Netherlands Cancer Institute-Antoni Van Leeuwenhoekziekenhuis (Amsterdam, Netherlands)
U.Z. Leuven - Campus Gasthuisberg (Leuven, Belgium)
UHB-Queen Elizabeth Medical Centre (Birmingham, United Kingdom)
UniversitaetsMedizin Mannheim (Mannheim, Germany)
Universitaetsklinikum Koeln (Koeln, Germany)
University College Hospital (London, United Kingdom)
University Hospitals Bristol NHS Foundation Trust - Bristol Haematology And Oncology Centre (Bristol, United Kingdom)
University Medical Center Groningen (Groningen, Netherlands)
Centers to be activated CHU de Toulouse - Institut Claudius Regaud - IUCT oncopole (TOULOUSE CEDEX 9, France)
Protocol summary
NCT number NCT01344018
Financial Support Academic Fund
External Grant