News from European Breast Cancer Conference
21 Mar 2018
EORTC Treat CTC study was presented today during the plenary session at the European Breast Cancer Conference in Barcelona, Spain. This Phase II study assessed whether trastuzumab decreases the detection rate of Circulating Tumour Cells (CTCs) compared to observation in women with HER2 non-amplified, non-metastatic breast cancer.
Circulating tumour cells are cells that detach from the primary tumour and move into the vascular or lymphatic system. These cells then attach themselves to other organs forming distant metastases and eventually causing a number of cancer related deaths. CTCs can be considered as “liquid biopsies” and can help to evaluate the disease status of a patient. However, there are differing results about the effectiveness of different treatments to reduce CTCs.
The EORTC 90091-10093 Treat CTC trial showed that, out of 1317 patients from 70 hospitals in five European countries, 95 patients had detectable CTC, 63 patients were randomly assigned to trastuzumab or observation. Fifty-eight patients were evaluable for the primary endpoint of CTC detection at week 18. It was found that, in this week, nine patients (five in the trastuzumab arm and four in the observation arm), still exhibited CTCs in their blood sample. Following a review by the Independent Data Monitoring Committee, further accrual to the study was stopped, as the trial could not meet its primary endpoint, it was viewed that even with continuous accrual this endpoint would never be met. The first year invasive disease free survival was 93.8% in the observational arm versus 84.8% in the trastuzumab arm. No grade 2-4 cardiac events were observed in the trastuzumab arm.
Leading investigator, Dr Michail Ignatiadis, Medical Oncologist at Jules Bordet Institute (IJB) and Assistant Professor at the Université Libre de Bruxelles, Brussels, Belgium, concluded that Trastuzumab does not decrease the detection rate of Circulating Tumor Cells in HER2 non-amplified, non-metastatic breast cancer. He said, “Although clearly a negative trial, the ‘Treat CTC’ introduced, for the first time, the use of liquid biopsy as a tool for precision medicine in early breast cancer.”
Related News
Meet the new EORTC Board
9 Jul 2024
We are pleased to announce the release of the EORTC 2023 Annual Report
17 Jun 2024
Dr Denis Lacombe, EORTC CEO, appointed stakeholder co-chair of ACT EU advisory group
24 May 2024
Clinical Trials Day 2024: a Q&A on pragmatic clinical trials
20 May 2024
EORTC/EMA workshop suggests an international way forward for treatment optimisation studies
8 May 2024
EORTC’s Participation at the ESTRO Congress 2024
29 Apr 2024
EORTC: Advancing research and treatment for rare cancers
29 Feb 2024
EORTC Fellowship Programme: celebrating more than 20 years of impactful collaboration
22 Feb 2024
Appointment of Malte Peters as EORTC Strategic Alliance Officer
9 Feb 2024
Unique series of workshops in partnership with the European Medicines Agency (EMA)
7 Feb 2024