EORTC has a strong track record in initiating and conducting clinical trials across thoracic cancers. The focus is not only lung cancer but also mesothelioma and thymomas. This follows EORTC strategy to challenge, re-define and develop standards of care for loco-regional as well as for systemic treatments.
Scientific projects are designed and conducted to integrate disciplines such as imaging, translational research, quality of life and quality assurance. There are multiple partnerships, especially with national groups in Europe but also with international umbrella organisations. The group places special emphasis on recruiting and mentoring junior colleagues who are interested in pursuing an academic career in the field of thoracic oncology.
Projects testing the place of immunotherapy in the treatment of lung cancer are also ongoing such as addressing the role of immunotherapy in the adjuvant setting of lung cancer.
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Nintedanib as maintenance treatment of malignant pleural mesothelioma (NEMO): a double-blind randomized phase II study of the EORTC Lung Cancer Group
EORTC randomized phase II study of pleurectomy/ decortication (P/D) preceded or followed by chemotherapy in patients with early stage malignant pleural mesothelioma
SPECTAlung: Screening Patients with thoracic tumors for Efficient Clinical Trial Access
A randomized, phase 3 trial with anti-PD-1 monoclonal antibody pembrolizumab (MK-3475) versus placebo for patients with early stage NSCLC after resection and completion of standard adjuvant therapy
A phase II study of etoposide and cis/carboplatin with or without pembrolizumab in untreated extensive small cell lung cancer
EORTC has contributed to changing the standards of care for thoracic oncology:
- 1459: Exploratory analysis of the pleural mesothelioma genome by next generation sequencing
- 1495: Update of OS in 08092 and CRP marker
- 1496: Survey on Thymoma / thymic malignancy
- 1549: Pharmacogenetic analysis from the double blind randomized phase III study ofmaintenance pazopanib versus placebo in NSCLC patients non progressive after first line chemotherapy. MAPPING, an EORTC Lung Group study
- 1557 Predict therapy in NSCLC: Studying changes in the expression of genes related to the metabolism and the chemotherapeutic activity in primary tumor and lymph and mediastinal lymph nodes infiltrated in resectable NSCLC
- 1638: Phase II, Parallel-Arm Study of MGCD265 in patients with locally advanced or metastatic NSCLC with Activating Genetic Alterations in Mesenchymal-Epithelial Transition Factor
IMI CANCER-ID – Cancer treatment and monitoring through identification of circulating tumor cells and tumor related nucleic acids in blood. EORTC is contributing with biological material and related data from EORTC study 1335 SPECTAlung.
European Reference Networks (ERN) for rare solid tumours (EURACAN). EURACAN is involving references centers in Europe covering ten types of rare cancers. EURACAN will improve patient cares and facilitate research in rare cancers. EORTC is providing the clinical research infrastructure. (No website available yet)
Gustave Roussy Cancer Campus
Academisch Ziekenhuis Maastricht
Institut Jules Bordet
C. Faivre-Finn - Manchester, GB
Early stage NSCLC & Radiotherapy
The Christie NHS Foundation Trust
J. Edwards - Sheffield , GB
Early stage NSCLC & Surgery
Sheffield Teaching Hospitals NHS Foundation Trust - Weston Park Hospital
M. Reck - Grosshansdorf, DE
L. Greillier - Marseille, FR
Malignant Pleural Mesothelioma
Assistance Publique - Hopitaux de Marseille - Hopital Nord
S. Lantuejoul - Grenoble, FR
Pathology & TR
CHU de Grenoble - Departement d'Anatomie et Cytologie Pathologiques
S. Novello - Orbassano, IT
Ospedale S. Luigi Gonzaga - Universita Di Torino
N. Girard - Paris, FR
M. O'Brien - Sutton, GB
Royal Marsden Hospital
L. Hendriks - Maastricht, NL
Young investigator lead
Academisch Ziekenhuis Maastricht
A. Levy - Villejuif, FR
Young investigator secretary
Diversity of brain metastases screening and management in non-small cell lung cancer in Europe: Results of the European Organisation for Research and Treatment of Cancer Lung Cancer Group survey
An international study to revise the EORTC questionnaire for assessing quality of life in lung cancer patients
European Organization for Research and Treatment of Cancer (EORTC) recommendations for planning and delivery of high-dose, high precision radiotherapy for lung cancer
Diversity of brain metastasis (BM) management in non-small cell lung cancer (NSCLC) in Europe (EU): Results of the Young Investigators European Organisation for Research and Treatment of Cancer Lung Cancer Group (YI EORTC LCG) survey. Poster Presentation at the ESMO Annual Meeting, Madrid, Spain, September 7 – 12, 2017.
Diagnostic and therapeutic strategies for elderly patients with advanced Non-Small cell lung cancer (NSCLC): results from an EORTC pan-european survey. Poster Presentation at the ESMO Annual Meeting, Madrid, Spain, September 7 – 12, 2017.