Tumours
Tumours

Brain

Description

The EORTC Brain Tumor Group (BTG) initiates and conducts academic clinical trials in patients with brain tumours, as well as designing and completing translational research associated with these trials. Its strategy is to challenge, re-define and develop standards of care in all controversial areas of diagnostic and therapeutic Neuro-Oncology, with a focus on diffuse gliomas of adulthood of WHO grades 2 to 4 and, in recent years, also meningioma. The BTG has created several subcommittees that help design and conduct its scientific projects and cover key aspects of all projects such as imaging, translational research, quality of life, and quality assurance. The BTG is open for cooperative projects involving other EORTC groups as well external cooperation, for example with Neuro-Oncology networks in Canada, Australia and the US. The group aims to recruit and mentor junior European colleagues from all involved disciplines who are interested in pursuing an academic career in Neuro-Oncology.

Main Achievements

In 2017, the EORTC 26101 trial published in the New England Journal of Medicine, demonstrated that the edition of bevacizumab to CCNU does not prolong overall survival, compared with CCNU alone in glioblastoma at first relapse. Interestingly, these trials results resulted in the continued approval of bevacizumab in this indication in the US and some other countries worldwide, including Switzerland, but not the European union.

In 2018 the EORTC trial, known as TAVAREC, demonstrated that the edition of bevacizumab to temozolomide at first relapse of contrast enhancing lower grade glioma without 1p/19q co-deletion, improved neither progression free survival nor overall survival adding to the accumulating evidence that bevacizumab is not active in IDH-mutant tumors.

In 2020, long-term follow-up of the CATNON trial confirmed the value of maintenance temozolomide treatment in newly diagnosed 1p/19q-non-co-deleted anaplastic gliomas, but still defined no certain role for concomitant temozolomide treatment. In 2022, the EORTC Brain Tumor Group completed the worldwide largest registry study on long-term survival in glioblastoma, enrolling more than 400 patients over several years. This study, known as EORTC 1419 or ETERNITY, will provide a rich source of opportunities to study the mechanisms underline long-term survival glioblastoma.

Research Group

Group documents
  • Chair

    Matthias Preusser

    Universitaetsklinikum Wien - AKH uniklinieken

    Vienna, Austria

  • Secretary

    Emilie Le Rhun

    UniversitaetsSpital Zurich - Neurology Clinic

    Zurich, Switzerland

  • Treasurer

    Giuseppe Minniti

    Policlinico Umberto I

    Rome, Italy

Steering Committee

  • M. Preusser - Vienna, AT

    CHAIR

    Universitaetsklinikum Wien - AKH uniklinieken

  • E. Le Rhun - Zurich, CH

    SECRETARY

    UniversitaetsSpital Zurich - Neurology Clinic

  • G. Minniti - Rome, IT

    TREASURER

    Policlinico Umberto I

  • M. Weller - Zurich, CH

    Past-Chair

    Universitätsspital Zürich

  • N. Albert - Munich, DE

    Chair Nuclear Medicine committee

    Ludwig Maximilian University of Munich

  • D. Brandsma - Amsterdam, NL

    Chair CNS Metastasis committee

    The Netherlands Cancer Institute-Antoni Van Leeuwenhoekziekenhuis

  • J. Duerinck - Brussels, BE

    Chair Neurosurgery committee

    Universitair Ziekenhuis Brussel

  • J. Furtner-Srajer - Krems-Stein, AT

    Chair Imaging committee

    Danube Private University

  • M. Jenkinson - Liverpool, UK

    Chair Meningioma committee

    The Walton Centre NHS Foundation Trust

  • P. Lohmann - Juelich, DE

    Chair Quality Assurance committee

    Forschungszentrum Juelich GmbH

  • A. Pace - Rome, IT

    Chair QoL committee

    IRCC Regina Elena national Cancer Center

  • F. Sahm - Heidelberg, DE

    Chair Pathology & Translational Research committee

    UniversitaetsKlinikum Heidelberg - Pathologisches Institut

  • M. Geurts - Rotterdam, NL

    E-YCI representative

    Erasmus MC

  • F. Ehret - Berlin, DE

    Early Career Investigator

    Charite - Universitaetsmedizin Berlin - Campus Virchow-Klinikum

  • M. Mair - Vienna, AT

    Early Career Investigator

    Universitaetsklinikum Wien - AKH unikliniken

  • M. Padovan - Padova, IT

    Early Career Investigator

    IRCCS - Istituto Oncologico Veneto

  • T. Picart - Lyon, FR

    Early Career Investigator

    CHU Lyon - Hopital neurologique Pierre Wertheimer

  • F. Ducray - Lyon , FR

    Top recruiter

    CHU Lyon - Hopital neurologique Pierre Wertheimer

  • G. Lombardi - Padova, IT

    Top recruiter

    IRCCS - Istituto Oncologico Veneto

  • E. Razis - Athens, GR

    EANO representative

    Hygeia Hospital

Pathology & Translational Research Committee

  • F. Sahm - Heidelberg, DE

    CHAIR

    UniversitaetsKlinikum Heidelberg - Pathologisches Institut

  • P. French - Rotterdam, NL

    Past-Chair

    Erasmus MC, University Medical Center Rotterdam

  • A. Wöhrer - Vienna, AT

    Medical University Vienna

  • M. Al-Hussaini - Amman, JO

    King Hussein Cancer Center

  • A. Suwala - Heidelberg, DE

    BTG-Y-ECI

    Heidelberg University Hospital

  • M. Geurts - Rotterdam, NL

    BTG-Y-ECI

    Erasmus MC

  • M. Weller - Zurich, CH

    Officer representative

    Universitätsspital Zürich

  • D. Bernhardt - Munich, DE

    Klinikum Rechts Der Isar,

  • L. Bertero - Turin, IT

    Laboratory of Azienda Ospedaliera Città della Salute e della Scienza di Torino

  • L. Bertero - Turin, IT

    Laboratory of Azienda Ospedaliera Città della Salute e della Scienza di Torino

  • G. Berzero - Milan, IT

    IRCCS Ospedale San Raffaele

  • C. Freyschlag - Innsbruck, AT

    Innsbruck Universitaetsklinik

  • M. Peyre - Paris, FR

    Hopital la Pitie-Salpetriere

  • N. Maas - Rotterdam, NL

    Erasmus MC

  • M. Neidert - St. Gallen, CH

    Kantonsspital St Gallen

  • F. Ricklefs - Hamburg, DE

    Universitaetsklinikum Hamburg

  • L. Schweizer - Frankfurt, DE

    University Hospital Frankfurt-Goethe University

  • B. Suchorska - Heidelberg, DE

    UniversitaetsKlinikum Heidelberg

  • P. Vollmuth - Heidelberg, DE

    UniversitaetsKlinikum Heidelberg

  • P. Wesseling - Amsterdam, NL

    Amsterdam UMC- Laboratories

  • V. Di Nunno - Bologna, IT

    IRCCS Ospedale Bellaria

Quality Assurance Committee

  • P. Lohmann - Juelich, DE

    Chair

    Forschungszentrum Juelich GmbH

  • J. Daisne - Leuven, BE

    Vice Chair

    U.Z. Leuven - Campus Gasthuisberg

  • E. Razis - Athens, GR

    Past-Chair

    Hygeia Hospital

  • G. Minniti - Rome, IT

    Officer representative

    Policlinico Umberto I

  • F. Sahm - Heidelberg, DE

    UniversitaetsKlinikum Heidelberg - Pathologisches Institut

  • P. Lohmann - Juelich, DE

    Forschungszentrum Juelich GmbH

  • M. Rasschaert - Edegem, BE

    Universitair Ziekenhuis Antwerpen (UZA)

  • A. Pellerino - Torino, IT

    Azienda Ospedaliera Città della Salute e della Scienza di Torino - Ospedale San Giovanni - Dipartimento Neuroscienze

  • F. Erhet - Berlin, DE

    YNO

    Charite - Universitaetsmedizin Berlin

  • M. Belting - Lund, SE

    Skane University Hospital

  • P. Brandal - Oslo , NO

    Oslo University Hospital

  • F. Ducray - Lyon , FR

    CHU Lyon - Hopital neurologique Pierre Wertheimer

Quality of Life Committee

  • A. Pace - Rome, IT

    Chair

    IRCC Regina Elena national Cancer Center

  • J. Koekkoek - Leiden , NL

    Vice Chair

    Leiden University Medical Centre

  • L. Dirven - Leiden, NL

    Past Chair

    Leiden University Medical Centre

  • E. Le Rhun - Zurich, CH

    Officer representative

    UniversitaetsSpital Zurich - Neurology Clinic

  • K. Oliver - Tadworth, UK

    Patient’s representative

    International Brain Tumour Alliance, IBTA

  • C. Seidel - Leipzig, DE

    Universitaetsklinikum Leipzig

  • P. Clement - Leuven, BE

    U.Z. Leuven - Campus Gasthuisberg

  • M. Renovanz - Tuebingen, DE

    Univ. Kliniken Tuebingen, Crona kliniken

  • M. Van der Meulen - Twente, NL

    Medisch Spectrum Twente

  • M. Mair - Vienna, AT

    YNO

    Universitaetsklinikum Wien - AKH unikliniken

  • H. Bulbeck - Isle of Wight, UK

    Patient’s representative

    Braintrust-the brain cancer poeple

  • C. Happold-Hertler - Zurich, CH

    Universitätsspital Zürich

  • L. Rosenlund - Stockholm, SE

    Regional Cancer Center Stockholm

  • T. Snijders - Utrecht, NL

    Universitair Medisch Centrum - Academisch Ziekenhuis

  • M. Wijnenga - Rotterdam, NL

    Erasmus MC

Imaging Committee

  • M. Weller - Zurich, CH

    Officer representative

    Universitätsspital Zürich

  • N. Albert - Munich, DE

    Nuclear medicine representative

    Ludwig Maximilian University of Munich

  • J. Furtner-Srajer - Krems-Stein, AT

    Chair

    Danube Private University

  • M. Smits - Rotterdam, NL

    Past-Chair

    Erasmus MC Cancer Institute

  • E. Tabouret - Marseille, FR

    Hopital de La Timone (APHM)

  • F. Cicone - , IT

    Mater Domini Univ. Hospital

  • P. Lohmann - Juelich, DE

    Forschungszentrum Juelich GmbH

  • T. Booth - London, UK

    School of Biomedical Engineering & Imaging Sciences King's College Hospital

  • J. Dankbaar - Utrecht, NL

    UMC-Academisch Ziekenhuis Utrecht

  • V. Keil - Amsterdam , NL

    Amsterdam UMC - locatie VUMC

  • P. Lohmann - Juelich, DE

    Forschungszentrum Juelich GmbH

  • K. Mankad - London, UK

    Great Ormond Street Hospital for Children

Meningioma Committee

  • M. Jenkinson - Liverpool, UK

    Chair

    The Walton Centre NHS Foundation Trust

  • E. Tabouret - Marseille, FR

    Vice Chair

    Hopital de La Timone (APHM)

  • M. Preusser - Vienna, AT

    Officer Representative and Past Chair

    Universitaetsklinikum Wien - AKH uniklinieken

  • J. Duerinck - Brussels, BE

    Universitair Ziekenhuis Brussel

  • T. Picart - Lyon, FR

    YNO

    CHU Lyon - Hopital neurologique Pierre Wertheimer

  • M. Padovan - Padova, IT

    YNO

    IRCCS - Istituto Oncologico Veneto

  • N. Andratschke - Zurich, CH

    UniversitaetsSpital Zurich

  • L. Fariselli - Milano, IT

    IRCCS - Istituto Neurologico Carlo Besta

  • A. Islim - Manchester, UK

    University Of Manchester

  • G. Lombardi - Padova, IT

    IRCCS - Istituto Oncologico Veneto

CNS Metastasis Committee

  • D. Brandsma - Amsterdam, NL

    Chair

    The Netherlands Cancer Institute-Antoni Van Leeuwenhoekziekenhuis

  • G. Lombardi - Padova, IT

    Vice Chair

    IRCCS - Istituto Oncologico Veneto

  • E. Le Rhun - Zurich, CH

    Past-Chair

    UniversitaetsSpital Zurich - Neurology Clinic

  • M. Preusser - Vienna, AT

    Officer representative

    Universitaetsklinikum Wien - AKH uniklinieken

  • N. Galldiks - Koeln, DE

    Universitaetsklinikum Koeln

  • G. Minniti - Rome, IT

    Policlinico Umberto I

  • J. Koekkoek - Leiden , NL

    Leiden University Medical Centre

  • A. Berghoff - Medical University Vienna - General Hospital AKH , AT

    Medical University Vienna

  • M. Mohme - Hamburg, DE

    Universitaetsklinikum Hamburg

  • E. Razis - Athens, GR

    Hygeia Hospital

  • P. Vollmuth - Heidelberg, DE

    UniversitaetsKlinikum Heidelberg

  • T. Weiss - Zurich, CH

    UniversitaetsSpital Zurich - Neurology Clinic

  • M. Padovan - Padova, IT

    YNO

    IRCCS - Istituto Oncologico Veneto

  • A. Pellerino - Torino, IT

    YNO

    Azienda Ospedaliera Città della Salute e della Scienza di Torino - Ospedale San Giovanni - Dipartimento Neuroscienze

Radiotherapy Committee

  • G. Minniti - Rome, IT

    Chair

    Policlinico Umberto I

  • S. Lukacova - Aarhus , DK

    Vice Chair

    Aarhus University Hospital

  • M. Preusser - Vienna, AT

    Officer representative

    Universitaetsklinikum Wien - AKH uniklinieken

  • D. Weber - Villigen, CH

    Paul Scherrer Institute - Center for Proton Therapy (CPT)

  • K. Niyazi - Munich, DE

    Ludwig-Maximilians-Universitaet Muenchen - Campus Grosshadern

  • T. Kazda - Brno, CZ

    Masaryk Memorial Cancer Institute

  • J. Furtner - Vienna , AT

    Medical University Vienna - General Hospital AKH

  • L. Fariselli - Milano, IT

    IRCCS - Istituto Neurologico Carlo Besta

  • D. Eekers - Maastricht, NL

    Maastro Clinic - Maastricht Radiation Oncology

  • F. Erhet - Berlin, DE

    Charite - Universitaetsmedizin Berlin

  • E. Moyal - Toulouse, FR

    CHU de Toulouse

  • P. Navarria - Rozzano, IT

    Istituto Clinico Humanitas

  • P. Roth - Zurich, CH

    UniversitaetsSpital Zurich

  • S. Short - Leeds, UK

    St James's University Hospital

Clinical Research Committee

  • M. Weller - Zurich, CH

    Chair

    Universitätsspital Zürich

  • E. Le Rhun - Zurich, CH

    UniversitaetsSpital Zurich - Neurology Clinic

  • M. Preusser - Vienna, AT

    Universitaetsklinikum Wien - AKH uniklinieken

  • G. Minniti - Rome, IT

    Policlinico Umberto I

Nuclear Medicine Committee

  • N. Albert - Munich, DE

    Chair

    Ludwig Maximilian University of Munich

  • N. Tolboom - Utrecht, NL

    Vice chair

    UMC Utrecht

  • M. Weller - Zurich, CH

    Officer representative

    Universitätsspital Zürich

  • J. Furtner - Vienna , AT

    Imaging group representative

    Medical University Vienna - General Hospital AKH

  • N. Galldiks - Koeln, DE

    Universitaetsklinikum Koeln

  • M. Preusser - Vienna, AT

    Universitaetsklinikum Wien - AKH uniklinieken

  • F. Cicone - , IT

    Mater Domini Univ. Hospital

  • A. Verger - Vandœuvre-lès-Nancy, FR

    CHRU de Nancy - Hopitaux De Brabois

  • A. Jakola - Gothenburg, SE

    Sahlgrenska Universitetssjukhuset

  • K. Niyazi - Munich, DE

    Ludwig-Maximilians-Universitaet Muenchen - Campus Grosshadern

  • M. Smits - Rotterdam, NL

    Erasmus MC Cancer Institute

  • M. Mair - Vienna, AT

    YNO

    Universitaetsklinikum Wien - AKH unikliniken

  • M. Broen - Maastricht, NL

    Academisch Ziekenhuis Maastricht

Neurosurgery Committee

  • J. Duerinck - Brussels, BE

    Chair

    Universitair Ziekenhuis Brussel

  • M. Weller - Zurich, CH

    Officer representative

    Universitätsspital Zürich

  • R. Grossman - Haifa, IL

    Rambam Health Care Campus, Oncology Institute

  • P. Karschnia - Munich, DE

    Ludwig-Maximilians-Universitaet Muenchen

  • M. Broekman - Leidschendam, NL

    HMC Antoniushove

  • G. Petrescu - Bucarest, RO

    "Bagdasar-Arseni" Emergency Clinical Hospital

  • A. Jakola - Gothenburg, SE

    Sahlgrenska Universitetssjukhuset

  • J. Gempt - Muenchen , DE

    Technische Universitaet Muenchen - Klinikum Rechts Der Isar

  • R. Goldbrunner - Koeln, DE

    Universitaetsklinikum Koeln

  • G. Widhalm - Vienna, AU

    Universitaetsklinikum Wien - AKH unikliniken

  • M. Neidert - St Gallen, CH

    Kantonsspital St Gallen

  • M. Jenkinson - Liverpool, UK

    The Walton Centre NHS Foundation Trust

  • T. Picart - Lyon, FR

    YNO

    CHU Lyon - Hopital neurologique Pierre Wertheimer

Neurocognition Committee

  • M. Preusser - Vienna, AT

    Chair

    Universitaetsklinikum Wien - AKH uniklinieken

  • E. Le Rhun - Zurich, CH

    Officer representative

    UniversitaetsSpital Zurich - Neurology Clinic

  • M. Klein - Amsterdam , NL

    Amsterdam UMC

  • E. Liouta - Athens, GR

    Evangelismos Hospital

  • G. Puglisi - Milan, IT

    University of Milan

  • K. Rosengarth - Regensburg, DE

    Universitaetsklinikum Regensburg

  • D. Satoer - Rotterdam, NL

    Erasmus MC

  • C. Sleurs - Tilburg, NL

    Tilburg University

  • B. Tomasino - Udine, IT

    Azienda Ospedaliero-Universitaria "Santa Maria della Misericordia"

Outreach Committee

  • E. Le Rhun - Zurich, CH

    Chair

    UniversitaetsSpital Zurich - Neurology Clinic

  • M. Preusser - Vienna, AT

    Officer representative/BTG Chair

    Universitaetsklinikum Wien - AKH uniklinieken

  • H. Bulbeck - Isle of Wight, UK

    Patient’s representative

    Braintrust-the brain cancer poeple

  • A. Azevedo - Lisbon, PT

    Instituto Portugues de Oncologia de Lisboa Francisco Gentil – EPE

  • M. Belting - Lund, SE

    Skane University Hospital

  • T. Kazda - Brno, CZ

    Masaryk Memorial Cancer Institute

  • S. Short - Leeds, UK

    St James's University Hospital

  • R. Grossman - Haifa, IL

    Rambam Health Care Campus, Oncology Institute

Committee(s)Close Committee(s)
Go to Top