Description
The Older Adult Council (OAC) is a think-tank to actively promote clinical and translational research in older adults with cancer both within EORTC and beyond. It will identify and define older adult research questions, address methodological questions (like frailty, quality of life, treatment toxicities, patient preferences, etc.), and guide the development of international initiatives that improve outcomes for older patients.
Why Research in Older Adults Matters?
Cancer disproportionately affects older adults, yet this population remains under‑represented in clinical trials, making evidence‑based decision‑making difficult in routine practice. Older individuals may experience frailty, comorbidities, or different treatment tolerances, all of which require specifically designed research approaches to ensure safe and effective cancer care.
EORTC is committed to reducing this evidence gap through patient‑centred research that integrates clinical, methodological, and translational innovation.
Main Achievements
The Elderly Minimal Dataset
A standardised Elderly Minimal Dataset (MinDS) allows to harmonise the collection of data relevant to the elderly and enable future cross-study and practice comparisons. All EORTC clinical trials use the Elderly Minimal Dataset, in particular, G8 screening for patients who are more than 70 years old.
Contribution to the development of an elderly-specific quality of life assessment tool, the QLQ-ELD14 module. This quality-of-life scale is already integrated in some studies of the elderly.
QLQ-ELD14: The OAC has contributed
to the development of an elderly-specific quality of life assessment tool, the QLQ-ELD14 module.
This quality-of-life scale is already integrated in some studies
OAC - Chairs
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ChairPaolo Bossi
Azienda Socio Sanitaria Territoriale Degli Spedali Civili di Brescia
Brescia, Italy
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Co-chairEmilie Le Rhun
UniversitaetsSpital Zurich - Neurology Clinic
Zurich, Switzerland
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Past chairLissandra Dal Lago
CHIREC
Brussels, Belgium
Additional People
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L. Dal Lago - Brussels, BE
Geriatric assessment, frailty assessment
CHIREC
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P. Bossi - Brescia, IT
Translational research, Competing mortality
Azienda Socio Sanitaria Territoriale Degli Spedali Civili di Brescia
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V. Thibaud - Lille, FR
Educational activities
Hopital Saint-Vincent de Paul
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P. Bonomo - Florence, IT
Patient’s preferences
Azienda Ospedaliero-Universitaria Careggi
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E. Le Rhun - Zurich, CH
Clinical trial design
UniversitaetsSpital Zurich - Neurology Clinic
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N. Luca Battisti - London, UK
ECI
The Royal Marsden NHS Foundation Trust
Notable Publications
All publications on this research field-
2022
Health-related Quality of Life (HRQoL) in older patients with HER2+ metastatic breast cancer: Comparing pertuzumab plus trastuzumab with or without metronomic chemotherapy in a randomised open-label phase II clinical trial
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2019
Cancer events in Belgian nursing home residents: An EORTC prospective cohort study
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1993
Commission of the European Communities - "Europe against Cancer" Programme - European School of Oncology Advisory Report. Cancer treatment in the elderly
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1993
Entry of elderly patients in EORTC new drug development studies. Proc. 29th Annual Meeting of the American Society of Clinical Oncology, Orlando, Florida, U.S.A., May 16-18, 1993 (abs. 329)
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2011
EORTC workshop on clinical trial methodology in older individuals with a diagnosis of solid tumors